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Quinidine Monosulfate

Quinidine Monosulfate

产品编号 T61517   CAS 50-54-4

Quinidine Monosulfate 是一种抗心律失常剂。Quinidine Monosulfate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂,也是 K+通道 (K+channel) 的有效阻断剂,其 IC50值为 19.9 μM。Quinidine Monosulfate 也可用作疟疾的研究。

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Quinidine Monosulfate Chemical Structure
Quinidine Monosulfate, CAS 50-54-4
规格 价格/CNY 货期 数量
25 mg ¥ 14,900 6-8周
50 mg ¥ 19,420 6-8周
100 mg ¥ 24,625 6-8周

Quinidine Monosulfate 的其他形式现货产品:

Quinidine Quinidine sulfate dihydrate Quinidine hydrochloride monohydrate
其他形式的 Quinidine Monosulfate:
药物设计专题培训
产品目录号及名称: Quinidine Monosulfate (T61517)
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存储 & 溶解度
产品描述 Quinidine Monosulfate is an antiarrhythmic agent. Quinidine Monosulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine Monosulfate is also a K + channel blocker with an IC 50 of 19.9 μM. Quinidine Monosulfate can be used for malaria research [1] [2] [3].
体外活性 Quinidine is an anti-arrythmic drug which affects ionic currents in heart muscle and which has also been shown to be a potent blocker of several classes of K + channel in a variety of cell types [1]. Bath application of quinidine causes a dose-dependent reduction of the peak amplitude of I k. The K d for blockade of I k at 0 mV is estimated to be 41 μM [1]. Quinidine elicits a dose-dependent increase of the rate of the decay of I k and this effect is enhanced by membrane depolarization. Quinidine also causes a 5 mV hyperpolarizing shift of the steady-state inactivation curve and increases the half-time for recovery from inactivation. Quinidine does not affect the onset of inactivation measured at -30 mV [1].
体内活性 Quinidine sulfate is rapidly absorbed, with peak plasma concentrations 60-90 min after an oral dose. Other salts (gluconate, polygalacturonate) are more slowly absorbed, with lower peak concentrations [2]. Quinidine is approximately 70-90 % bound to plasma proteins. It undergoes hepatic oxidative metabolism to form an N-oxide, a 3-hydroxy form, an O-demethyl form and 2'-quinidinone. Over one-half of patients starting quinidine stop within the first year of therapy because of side effects. These include, commonly, diarrhea, nausea, and vomiting which are not necessarily related to high plasma concentrations [2]. Quinidine inhibits metabolism of amphetamine in rats. Quinidine pretreatment results in a significant decrease in the excretion of p-hydroxyamphetamine at 24 and 48 h to 7.2 and 24.1% of the vehicle-control levels, respectively, accompanied by a significant increase in amphetamine excretion between 24 and 48 h to 542% of the control [3].
分子量 746.92
分子式 C40H50N4O8S
CAS No. 50-54-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Quinidine Monosulfate 50-54-4 Inhibitor inhibitor inhibit

 

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