规格

价格

库存

数量

50 mg

¥ 298

现货

100 mg

¥ 418

现货

1 g

¥ 629

现货

1 mL x 10 mM (in DMSO)

¥ 460

现货

生物活性

产品描述	Clindamycin hydrochloride (Clinimycin HCl) inhibits protein synthesis by acting on the 50S ribosomal. It is the hydrochloride salt form of clindamycin, a semi-synthetic, chlorinated broad-spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin hydrochloride(Clinimycin HCl) is used as a solid in capsules.
体外活性	Clindamycin是一种经典的细菌蛋白质合成抑制剂，它通过结合到50S核糖体亚基的23S核糖体RNA上发挥作用。[1]
体内活性	Clindamycin hydrochloride 口服给犬类后可快速吸收，平均吸收时间 (MAT) 为 0.87 小时，生物利用度为 72.55%。无论是通过静脉注射 (IV) 还是口服给药，Clindamycin hydrochloride 在犬类体内的总清除率 (CL) 分别为 0.503 和 0.458 L/h/kg。其在稳态时的分布容积 (IV) 为 2.48 L/kg，表明克林默素在体液和组织中分布广泛。Clindamycin hydrochloride 在静脉注射和口服给药后的血清浓度能在大约 10 小时内保持在 0.5 μg/mL 以上。[1] Clindamycin hydrochloride 显著减少犬类口腔异味，自基线水平起至 42 天。同时，它也显著降低了牙齿菌斑、牙石和牙龈出血。[2] 在超声牙石清除、根面平整及抛光 (USRP) 后，Clindamycin hydrochloride (2.5 mg/lb) 显著影响牙周病的牙菌斑和袋深度指标，但对犬类牙龈炎无明显效果。[3] 在 14 至 28 天内治疗，Clindamycin hydrochloride 使犬类浅表性细菌性皮肤炎的完全缓解率达到 71.4% (15/21)。[4]
激酶实验	In vitro potency assays: After RO4929097 is used, the Aβ peptides are measured by ECL assays using a variety of anti-Aβ antibodies and an Origen 1.5 Analyzer. The 4 g8 murine mAb binds an epitope in the Aβ peptide (within amino acids 18–21) that is immediately distal to the α-secretase cleavage site. The G2–10 murine mAb binds the C terminus that is exposed after γ-secretase-mediated cleavage to generate amino acid 40 of the Aβ40 peptide. The FCA3542 rabbit antibody binds the C terminus that is exposed after γ-secretase-mediated cleavage to generate amino acid 42 of the Aβ42 peptide. The 4 g8 mAb is biotinylated with biotin-LC-sulfo-N-hydroxysuccinimide-ester. The G2–10 and FCA3542 antibodies are ruthenylated with TAG-N-hydroxysuccinimide ester. Aβ(x-40) is detected with biotinylated 4 g8 and ruthenylated G2–10. Aβ(x-42) is detected with biotinylated 4 g8 and ruthenylated FCA3542.
别名	盐酸克林霉素, Sobelin HCl, Clinimycin HCl, Clindamycin HCl, Cleocin

化学信息

分子量	461.44
分子式	C₁₈H₃₃ClN₂O₅S·HCl
CAS No.	21462-39-5
Smiles	Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 250 mg/mL (541.78 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.33 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1671 mL	10.8356 mL	21.6713 mL	108.3564 mL
5 mM	0.4334 mL	2.1671 mL	4.3343 mL	21.6713 mL
10 mM	0.2167 mL	1.0836 mL	2.1671 mL	10.8356 mL
20 mM	0.1084 mL	0.5418 mL	1.0836 mL	5.4178 mL
50 mM	0.0433 mL	0.2167 mL	0.4334 mL	2.1671 mL
100 mM	0.0217 mL	0.1084 mL	0.2167 mL	1.0836 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Clindamycin hydrochloride

Clindamycin hydrochloride

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Clindamycin hydrochloride

Clindamycin hydrochloride