Dehydroevodiamine

Name: Dehydroevodiamine
Brand: TargetMol
SKU: T2S2335
Price: 169 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.54%

货号 T2S2335Cas号 67909-49-3

别名 脱氢吴茱萸碱, 去氢吴茱萸碱, DHED

Dehydroevodiamine (DHED) 是从吴茱萸中分离出的一种喹唑啉生物碱，可抑制 LPS 诱导的小鼠巨噬细胞中iNOS、COX-2、PGE2和NF-κB 的表达，对豚鼠心室肌细胞具有抗心律失常作用。

Dehydroevodiamine

一键复制产品信息

很棒

纯度: 99.54%

货号 T2S2335 别名 脱氢吴茱萸碱, 去氢吴茱萸碱, DHEDCas号 67909-49-3

规格	价格	库存
1 mg	¥ 169	现货
2 mg	¥ 233	现货
5 mg	¥ 372	现货
10 mg	¥ 496	现货
25 mg	¥ 818	现货
50 mg	¥ 1,190	现货
100 mg	¥ 1,790	现货

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产品介绍

Dehydroevodiamine AI Summary

Dehydroevodiamine is a bioactive molecule known for its diverse pharmacological properties. It acts as an inhibitor of Cytochrome P450 enzymes with varying potencies: it has a moderate inhibitory effect on Cytochrome P450 1A1 (IC50 = 18050.0 nM), a stronger inhibition on Cytochrome P450 1A2 (IC50 = 5630.0 nM), and potent inhibition on Cytochrome P450 1B1 (IC50 = 330.0 nM), displaying higher selectivity towards P450 1B1. Additionally, Dehydroevodiamine demonstrates vasodilatory effects in rat thoracic aortic rings by inhibiting phenylephrine-induced contractions, with an EC50 range of 1600.0 nM to 7780.0 nM, depending on the experimental conditions. It also acts as an antagonist at the alpha-adrenoceptor with a dissociation constant (Kd) of 128.82 nM and can displace [3H]prazosin from the alpha1 adrenoceptor with a Ki of 2400.0 nM. The compound can displace [3H]8-OH-DPAT from the 5HT1A receptor with a K_i of 36000.0 nM. Its antiinflammatory activity is evident in IFN-gamma/LPS-stimulated mouse RAW264.7 cells, where it inhibits NO production, particularly when pre-treatment occurs before IFN-gamma stimulation. The antiinflammatory effects are dose-dependent, showing significant inhibition at 10 μM and retaining activity post-LPS addition, though less effectively than pre-stimulation treatment..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.
别名	脱氢吴茱萸碱, 去氢吴茱萸碱, DHED

化学信息

分子量	301.34
分子式	C₁₉H₁₅N₃O
CAS No.	67909-49-3
Smiles	C[n+]1c2-c3[n-]c4ccccc4c3CCn2c(=O)c2ccccc12
密度	no data available
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 16.67 mg/mL (55.32 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Saline: 1 mg/mL (3.32 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3185 mL	16.5926 mL	33.1851 mL	165.9255 mL
5 mM	0.6637 mL	3.3185 mL	6.6370 mL	33.1851 mL
10 mM	0.3319 mL	1.6593 mL	3.3185 mL	16.5926 mL
20 mM	0.1659 mL	0.8296 mL	1.6593 mL	8.2963 mL
50 mM	0.0664 mL	0.3319 mL	0.6637 mL	3.3185 mL