CaMKII-IN-1

Name: CaMKII-IN-1
Brand: TargetMol
SKU: T14860
Price: 532 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.69%

货号 T14860Cas号 1208123-85-6

CaMKII-IN-1是高效的 CaMKII 选择性抑制剂，IC50为63nM，对 CaMKIV, MLCK, p38a, Akt1,和 PKC 这些靶点几乎无作用。

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CaMKII-IN-1

一键复制产品信息

很棒

纯度: 99.69%

货号 T14860Cas号 1208123-85-6

CaMKII-IN-1是高效的 CaMKII 选择性抑制剂，IC50为63nM，对 CaMKIV, MLCK, p38a, Akt1,和 PKC 这些靶点几乎无作用。

规格	价格	库存
1 mg	¥ 532	现货
2 mg	¥ 768	现货
5 mg	¥ 1,230	现货
10 mg	¥ 1,830	现货
25 mg	¥ 3,730	现货
50 mg	¥ 5,450	现货
100 mg	¥ 7,650	现货
1 mL x 10 mM (in DMSO)	¥ 1,480	现货

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纯度: 99.69%

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COA LCMS HNMR 产品操作手册

产品介绍

CaMKII-IN-1 AI Summary

CaMKII-IN-1 demonstrates bioactivity as a kinase inhibitor with varying levels of potency based on IC50 values: CAMK4 (> 60,000 nM), MLCK (36,000 nM), p38alpha (11,000 nM), AKT1 (30,000 nM), PKC (21,000 nM), and CAMK2 (63 nM). Additionally, CaMKII-IN-1 exhibits antiviral activity against SARS-CoV-2 by reducing cytotoxicity in Caco-2 cells (Inhibition = -9.62% at 10 µM after 48 hours) and in VERO-6 cells (Inhibition = -0.11% at 10 µM after 48 hours with 0.01 MOI virus) as assessed by high content imaging. The compound also inhibits SARS-CoV-2 3CL-Pro protease activity, showing 7.665% inhibition at 20 µM concentration. Furthermore, CaMKII-IN-1 inhibits the human HDAC6 enzyme, with a significant inhibition of -51.21% observed using a commercial peptide substrate, compared to -6.46% with a custom peptide substrate. These results suggest that CaMKII-IN-1 has diversified inhibitory effects on kinases, antiviral properties against SARS-CoV-2, and potential activity as an HDAC6 inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM). CaMKII-IN-1 exhibited more than 100-fold higher selectivity for CaMKII over CaMKIV, MLCK, p38a, Akt1, and PKC.
靶点活性	CaMK II:63 nM

化学信息

分子量	548.1
分子式	C₂₉H₃₀ClN₅O₂S
CAS No.	1208123-85-6
Smiles	Cc1c(Cl)cccc1S(=O)(=O)Nc1nc(NCCc2ccccc2)nc2CCN(Cc3ccccc3)Cc12
密度	1.349 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 54 mg/mL (98.52 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8245 mL	9.1224 mL	18.2448 mL	91.2242 mL
5 mM	0.3649 mL	1.8245 mL	3.6490 mL	18.2448 mL
10 mM	0.1824 mL	0.9122 mL	1.8245 mL	9.1224 mL
20 mM	0.0912 mL	0.4561 mL	0.9122 mL	4.5612 mL
50 mM	0.0365 mL	0.1824 mL	0.3649 mL	1.8245 mL