规格

价格

库存

数量

1 mg

¥ 253

现货

5 mg

¥ 592

现货

10 mg

¥ 960

现货

25 mg

¥ 1,870

现货

50 mg

¥ 2,820

现货

100 mg

¥ 4,070

现货

1 mL x 10 mM (in DMSO)

¥ 718

现货

生物活性

产品描述	T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 μM),and functions as a calcium-activated chloride channel (CaCC).
靶点活性	TMEM16A (Cl- channel):1 µM
体外活性	T16Ainh-A01（0.3-30μM）能显著降低IClCa的内向和外向分量，并在不明显影响L型Ca2+电流的情况下抑制RUICC中的IClCa。T16Ainh-A01（10μM）在所有电压下几乎完全抑制由管内275 nM自由钙诱导的TMEM16A氯电流，表明其为电压独立的阻断机制。

化学信息

分子量	416.52
分子式	C₁₉H₂₀N₄O₃S₂
CAS No.	552309-42-9
Smiles	CCc1c(C)[nH]c(SCC(=O)Nc2nc(cs2)-c2ccc(OC)cc2)nc1=O
密度	1.39 g/cm3 (Predicted)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: Insoluble

DMF: 10 mg/mL (24.01 mM), Sonication is recommended.

DMSO: 83.33 mg/mL (200.06 mM), Sonication is recommended.

溶液配制表

DMF/DMSO