Name: GSK621
Brand: TargetMol
SKU: T6854
Price: 389 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 389

现货

5 mg

¥ 995

现货

10 mg

¥ 1,730

现货

25 mg

¥ 3,580

现货

50 mg

¥ 5,170

现货

100 mg

¥ 7,280

现货

500 mg

¥ 14,600

现货

产品介绍

生物活性

产品描述	GSK621 is a specific and potent AMPK activator.
体外活性	在AML细胞系和初级AML样本中，GSK621显著增强了AMPKα T172位点的磷酸化，这是AMPK激活的标志。在一组20个细胞系中，GSK621抑制了所有20个细胞系的增殖，IC50范围为13-30 μM，并在17个（占85%）细胞系中增加了凋亡。此外，GSK621还触发了自噬，这部分促成了AML细胞的死亡。[1]
体内活性	在裸鼠体内携带MOLM-14异种移植物的实验中，GSK621（30 mg/kg, i.p.）通过增强AMPK活性和诱导凋亡，有效降低了白血病的生长速度并显著延长了生存期。[1]
激酶实验	AMPK enzymatic assay: HEPG2 cells are treated with increasing doses of A-769662 or GSK621, and ACC S79 phosphorylation is assessed as a surrogate marker for AMPK activation using a commercially available ELISA kit.
细胞实验	Twenty AML cell lines are treated with log10 dilutions of GSK621 and relative viability is determined by CellTiter-Glo?assay. IC50 of GSK621 among these 20 cell lines is calculated using the Prism software and are presented as log[C] with [C] in mol/l (M). Results are presented for 5 different cell lines per panel.(Only for Reference)

化学信息

分子量	489.91
分子式	C₂₆H₂₀ClN₃O₅
CAS No.	1346607-05-3
Smiles	COc1cccc(c1)-n1c(=O)[nH]c2cc(Cl)n(-c3ccc(cc3)-c3cccc(OC)c3O)c2c1=O
密度	1.41 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 90 mg/mL (183.71 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+90% Corn Oil: 1 mg/mL (2.04 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

体内实验配液计算器