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Deracoxib

Name: Deracoxib
Brand: TargetMol
SKU: T0484
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 地拉考昔, SC 59046, SC 46, SC 046

货号 T0484Cas号 169590-41-4 一键复制产品信息纯度: 99.81%

很棒

Deracoxib (SC 46) 是非甾体、非麻醉性抗炎药。它也是选择性 cyclooxygenase-2 抑制剂，IC50 值：70 至 150 μM，抑制 3 种骨肉瘤细胞系。

Deracoxib

一键复制产品信息

很棒

纯度: 99.81%

货号 T0484Cas号 169590-41-4

别名 地拉考昔, SC 59046, SC 46, SC 046

Deracoxib (SC 46) 是非甾体、非麻醉性抗炎药。它也是选择性 cyclooxygenase-2 抑制剂，IC50 值：70 至 150 μM，抑制 3 种骨肉瘤细胞系。

规格	价格	库存
5 mg	¥ 99	现货
10 mg	¥ 123	现货
25 mg	¥ 247	现货
50 mg	¥ 372	现货
100 mg	¥ 558	现货
500 mg	¥ 1,680	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.81%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Deracoxib AI Summary

Deracoxib is a multifunctional inhibitor with diverse biological activities. It strongly inhibits human Prostaglandin G/H synthase 2 (COX-2) with an IC50 of 50.12 nM and shows activity against human recombinant COX-2 with an IC50 of 50.0 nM. It also inhibits human COX-1 with a higher IC50 of 36,000 nM. In canine models, it inhibits prostaglandin G/H synthase 1 with an IC50 of 23,000 nM and COX-2 with an IC50 of 630 nM, yielding a COX-1/COX-2 selectivity ratio of 36.5. In rat models, Deracoxib demonstrated effective anti-inflammatory and analgesic properties, with ED50 values of 0.05 mg.kg-1 in the adjuvant-induced arthritis assay, 18.6 mg.kg-1 in the carrageenan-induced foot pad edema assay, and 33.0 mg.kg-1 in the carrageenan-induced hyperalgesia assay. Notably, it caused no ulceration at a dose of 200 mg/kg and had a plasma half-life of 3.5 hours following intravenous administration. The compound also inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 39.81 μM and exhibits potent antiviral activity, including inhibition of Ebola Virus entry and SARS-CoV-2 induced cytotoxicity in multiple cell lines. It effectively blocks fluorescence uptake in OATP1B3- and OATP1B1-transfected CHO cells, indicating high transporter inhibitory potential. Additionally, Deracoxib shows a LogD7.4 value of 2.8 and a plasma protein binding (PPB) of 97.32%. It inhibits the BSEP with an IC50 of 20,180 nM, and its antiviral properties extend to inhibiting SARS-CoV-2 induced cytotoxicity, exhibiting modest effects on viral 3CL-Pro protease activity, and showing promising inhibition percentages against SARS-CoV-2 in various assays. Finally, Deracoxib also displays modest inhibitory activity on the human HDAC6 enzyme with minor variability depending on the substrate used..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Deracoxib (SC 46) is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 μM(inhibition of 3 osteosarcoma cell lines).
靶点活性	COX-2:70-150 μM
别名	地拉考昔, SC 59046, SC 46, SC 046

化学信息

分子量	397.37
分子式	C₁₇H₁₄F₃N₃O₃S
CAS No.	169590-41-4
Smiles	COc1ccc(cc1F)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)F
密度	1.48 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 60 mg/mL (150.99 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.03 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5165 mL	12.5827 mL	25.1655 mL	125.8273 mL
5 mM	0.5033 mL	2.5165 mL	5.0331 mL	25.1655 mL
10 mM	0.2517 mL	1.2583 mL	2.5165 mL	12.5827 mL
20 mM	0.1258 mL	0.6291 mL	1.2583 mL	6.2914 mL
50 mM	0.0503 mL	0.2517 mL	0.5033 mL	2.5165 mL
100 mM	0.0252 mL	0.1258 mL	0.2517 mL	1.2583 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。