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Seratrodast

Name: Seratrodast
Brand: TargetMol
SKU: T0212
Price: 255 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.69%

货号 T0212Cas号 112665-43-7

别名 塞曲司特, ABT-001, AA 2414

Seratrodast (ABT-001) 是一种血栓素 A2 受体 (TP) 拮抗剂，用于治疗哮喘。

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Seratrodast

一键复制产品信息

很棒

纯度: 99.69%

货号 T0212 别名 塞曲司特, ABT-001, AA 2414Cas号 112665-43-7

Seratrodast (ABT-001) 是一种血栓素 A2 受体 (TP) 拮抗剂，用于治疗哮喘。

规格	价格	库存
5 mg	¥ 255	现货
10 mg	¥ 413	现货
25 mg	¥ 637	现货
50 mg	¥ 828	现货
100 mg	¥ 1,370	现货
200 mg	¥ 2,080	现货
500 mg	¥ 3,530	现货
1 mL x 10 mM (in DMSO)	¥ 327	现货

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纯度: 99.69%

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COA HNMR LCMS 产品操作手册

产品介绍

Seratrodast AI Summary

Seratrodast exhibits a broad range of bioactivities across multiple assays and targets. It shows potent inhibition of U-46619-induced contraction of guinea pig lung membranes (Kd = 5.129 nM) and U-44069-induced aggregation of guinea pig platelets (IC50 = 350.0 nM). Demonstrating significant efficacy in various biological systems, it effectively inhibits U-44,069-induced contraction of rabbit aorta and platelet aggregation, and possesses anti-bronchoconstriction properties validated by in vivo studies. Despite this, its inhibition effects on the vitamin D receptor, malarial parasite plastid, USP1/UAF1, and others, display significantly lower potency, most notably with USP1/UAF1 (89,125.1 nM) and vitamin D receptor (44,668.4 nM). Seratrodast shows moderate metabolic stability with high lipophilicity (LogD7.4 = 2.48), an intrinsic clearance of 85.0 uL.min-1.(10^6 cells)-1 in rat hepatocytes, and 3.0 mL.min-1.g-1 in human liver microsomes. It exhibits a high plasma protein binding of 98.0%. It also acts as an inhibitor of human BSEP (IC50 < 14,310.0 nM) and shows mixed results on cell viability across various cell types, such as HEK293T and U2OS cells. While exhibiting some antiviral activities against SARS-CoV-2 and Ebola Virus with low and mixed inhibitory effects, Seratrodast also demonstrates HDAC6 inhibition (36.44% inhibition in enzyme assay). Additionally, it affects the thermal stability of various protein domains and has significant, though variable, impacts on GPCR beta-arrestin recruitment assays across multiple targets. Overall, Seratrodast has significant potential in anti-inflammatory and anti-contraction applications with a diverse range of biological activities, though with relatively lower potency against several enzymes and receptors..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist developed as an anti-asthmatic drug and attained marketing qualification in Japan in 1997.
别名	塞曲司特, ABT-001, AA 2414

化学信息

分子量	354.44
分子式	C₂₂H₂₆O₄
CAS No.	112665-43-7
Smiles	C(CCCCCC(O)=O)(C1=C(C)C(=O)C(C)=C(C)C1=O)C2=CC=CC=C2
密度	1.14 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (141.07 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Saline: 2.5 mg/mL (7.05 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8214 mL	14.1068 mL	28.2135 mL	141.0676 mL
5 mM	0.5643 mL	2.8214 mL	5.6427 mL	28.2135 mL
10 mM	0.2821 mL	1.4107 mL	2.8214 mL	14.1068 mL
20 mM	0.1411 mL	0.7053 mL	1.4107 mL	7.0534 mL
50 mM	0.0564 mL	0.2821 mL	0.5643 mL	2.8214 mL
100 mM	0.0282 mL	0.1411 mL	0.2821 mL	1.4107 mL