CETP

Obicetrapib (AMG-899) 是胆固醇酯转移蛋白的抑制剂。

Dalcetrapib (RO4607381) 是rhCETP 抑制剂(IC50:0.2 μM)，具有增加血浆中HDL 胆固醇含量的作用。

Evacetrapib (LY2484595) 是 CETP 的选择性抑制剂，在人血浆中，抑制人重组 CETP 蛋白 (IC50:5.5 nM) 和 CETP (IC50:36 nM) 活性。

是胆固醇酯转移蛋白 (CETP) 选择性抑制剂。根据人血浆的抑制曲线，Torcetrapib (CP-529414) 对CETP 的最有效浓度为 37 nM。

Anacetrapib (MK-0859) 是 CETP 的抑制剂，能够抑制 rhCETP (IC50:7.9±2.5 nM) 和 C13S CETP 突变型 (IC50:11.8±1.9 nM) 的活性。

20-HC-Me-Pyrrolidine是一种有效的Aster蛋白抑制剂，对 Aster-A、Aster-B 和 Aster-C 的 IC50=0.06~0.71 μm，能够阻断Aster蛋白结合和转移胆固醇的能力，包括抑制LDL胆固醇向内质网的移动。

3-Pyridinemethanol (Roniacol) 是一种具有降胆固醇作用的吡啶衍生物。

CETP-IN-3 is an inhibitor of the plasma glycoprotein cholesterol ester transfer protein (CETP), elevating HDL-C through inhibition of CETP.

CETP-IN-4 is a cholesteryl ester transfer protein (CETP) inhibitor.

alpha-Amyl cinnamaldehyde is a common additive in the perfume and cosmetic industry as an aroma substance.

Monometacrine 是一种胆固醇酯酶抑制剂，具有抗抑郁作用。

Canosimibe is a cholesterol absorption inhibitor

Erabulenol A 是一种胆固醇酯转移蛋白（CETP）抑制剂，可从 Penicillum sp. 中提取获得。

CKD-519 is a selective inhibitor of cholesteryl ester transfer protein (CETP). It inhibits CETP-mediated transfer of cholesteryl ester in human serum (IC50: 2.3 nM).

Potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable. Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID:26524347

Rosenonolactone exhibits inhibitory activity against prolyl endopeptidase and thrombin.

Azacosterol is a diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase causing accumulation of desmosterol. Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol. Although it primarily acts to inhibit 24-DHCR, the drug also inhibits other steps in cholesterol biosynthesis. The antifertility effects of the drug in birds are mediated by inhibition of steroid hormone production, steroid hormones being synthesized from cholesterol.

TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).

CP 524515 是一种胆固醇酯转移蛋白 (CETP) 的有效抑制剂，能够增加高密度脂蛋白胆固醇水平。

CP-532623, a close structural analog of Torcetrapib, is a CETP inhibitor with highly lipophilic properties. It elevates high-density lipoprotein cholesterol.

MK-8262, an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor (IC 50 = 53 nM, log D = 5.3), is a bistrifluoromethyl analogue that shows promise in research related to high-density lipoprotein (HDL) and low-density lipoprotein (LDL) with potential implications for coronary heart disease (CHD).

Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).

BMS-188494 is a squalene synthase inhibitor used as an anti-cholesterol drug.