购物车
您的购物车当前为空
exo-IWR-1
一键复制产品信息
很棒纯度: 97.41%
货号 T22775Cas号 1127442-87-8
别名 exo-IWR 1
exo-IWR-1 (exo-IWR 1) 是一种 IWR-1 的阴性对照无活性异构体。其中IWR-1是一种端锚聚合酶抑制剂，能够抑制Wnt/β-catenin 信号传导途径。
其他形式的 “exo-IWR-1”:
为众多的药物研发团队赋能，
让新药发现更简单！
exo-IWR-1
一键复制产品信息 很棒纯度: 97.41%
货号 T22775 别名 exo-IWR 1Cas号 1127442-87-8
exo-IWR-1 (exo-IWR 1) 是一种 IWR-1 的阴性对照无活性异构体。其中IWR-1是一种端锚聚合酶抑制剂，能够抑制Wnt/β-catenin 信号传导途径。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 119 | 现货 | |
| 5 mg | ¥ 200 | 现货 | |
| 10 mg | ¥ 329 | 现货 | |
| 25 mg | ¥ 691 | 现货 | |
| 50 mg | ¥ 1,230 | 现货 | |
| 100 mg | ¥ 1,830 | 现货 | |
| 200 mg | ¥ 2,620 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 248 | 现货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
产品介绍
exo-IWR-1 AI Summary
exo-IWR-1 is a multifunctional inhibitor targeting several biological pathways and exhibiting notable bioactivity. It inhibits the Wnt3 signaling pathway by targeting the Wnt/catenin pathway with an EC50 value of 5000.0 nM, as shown in assays involving mouse L-cells. The compound also demonstrates inhibition of the N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 cells, with a similar EC50 value of 5000.0 nM. Additionally, it inhibits 6XHis-tagged tankyrase1 with an IC50 value of 1000.0 nM and significantly targets the ADP-ribosyltransferase catalytic domains of human TNKS1 and TNKS2, showing greater potency against TNKS2 (IC50 = 29.2 nM) compared to TNKS1 (IC50 = 303.0 nM).
In terms of antiviral activity, exo-IWR-1 inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a 10 µM concentration with a 1.68% inhibition rate after 48 hours. It also shows inhibition against the SARS-CoV-2 3CL-Pro protease by 4.771% at a concentration of 20 µM. Furthermore, in VERO-6 cells, the compound exhibits a 0.12% inhibition rate at the same 10 µM concentration after 48 hours of exposure to the SARS-CoV-2 virus.
Moreover, exo-IWR-1 displays inhibitory activity against human HDAC6, with an inhibition of -1.4% using a commercial peptide substrate and 4.47% using a custom peptide substrate. This compound's diverse inhibitory effects suggest potential applications in both cancer research and antiviral therapeutics..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. |
| 别名 | exo-IWR 1 |
| 分子量 | 409.44 |
| 分子式 | C25H19N3O3 |
| CAS No. | 1127442-87-8 |
| Smiles | [H][C@@]12C[C@]([H])(C=C1)[C@@]1([H])C(=O)N(C(=O)[C@@]21[H])c1ccc(cc1)C(=O)Nc1cccc2cccnc12 |
| 密度 | 1.425 g/cm3 (Predicted) |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| 溶解度信息 | DMSO: 12 mg/mL (29.31 mM), Sonication is recommended.  | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
预览
Related Tags: buy exo-IWR-1 | purchase exo-IWR-1 | exo-IWR-1 cost | order exo-IWR-1 | exo-IWR-1 chemical structure | exo-IWR-1 formula | exo-IWR-1 molecular weight
嗨！有任何问题？点我咨询
版权所有©2015-2026 TargetMol Chemicals Inc.保留所有权利.
沪ICP备20019793号-4 | 沪公网安备 31010602006700号
| 沪(静)应急管危经许[2024]203441