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exo-IWR-1

Name: exo-IWR-1
Brand: TargetMol
SKU: T22775
Price: 119 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: exo-IWR 1

货号 T22775Cas号 1127442-87-8 一键复制产品信息纯度: 97.41%

很棒

exo-IWR-1 (exo-IWR 1) 是一种 IWR-1 的阴性对照无活性异构体。其中IWR-1是一种端锚聚合酶抑制剂，能够抑制Wnt/β-catenin 信号传导途径。

exo-IWR-1

一键复制产品信息

很棒

纯度: 97.41%

货号 T22775Cas号 1127442-87-8

别名 exo-IWR 1

exo-IWR-1 (exo-IWR 1) 是一种 IWR-1 的阴性对照无活性异构体。其中IWR-1是一种端锚聚合酶抑制剂，能够抑制Wnt/β-catenin 信号传导途径。

规格	价格	库存
2 mg	¥ 119	现货
5 mg	¥ 200	现货
10 mg	¥ 329	现货
25 mg	¥ 691	现货
50 mg	¥ 1,230	现货
100 mg	¥ 1,830	现货
200 mg	¥ 2,620	现货
1 mL x 10 mM (in DMSO)	¥ 248	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务。

实验操作小课堂

常见问题解答

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纯度: 97.41%

颜色: 黄色

性状: Solid

资源下载: COA LCMS HNMR HPLC产品操作手册

产品介绍

exo-IWR-1 AI Summary

exo-IWR-1 is a multifunctional inhibitor targeting several biological pathways and exhibiting notable bioactivity. It inhibits the Wnt3 signaling pathway by targeting the Wnt/catenin pathway with an EC50 value of 5000.0 nM, as shown in assays involving mouse L-cells. The compound also demonstrates inhibition of the N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 cells, with a similar EC50 value of 5000.0 nM. Additionally, it inhibits 6XHis-tagged tankyrase1 with an IC50 value of 1000.0 nM and significantly targets the ADP-ribosyltransferase catalytic domains of human TNKS1 and TNKS2, showing greater potency against TNKS2 (IC50 = 29.2 nM) compared to TNKS1 (IC50 = 303.0 nM). In terms of antiviral activity, exo-IWR-1 inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a 10 µM concentration with a 1.68% inhibition rate after 48 hours. It also shows inhibition against the SARS-CoV-2 3CL-Pro protease by 4.771% at a concentration of 20 µM. Furthermore, in VERO-6 cells, the compound exhibits a 0.12% inhibition rate at the same 10 µM concentration after 48 hours of exposure to the SARS-CoV-2 virus. Moreover, exo-IWR-1 displays inhibitory activity against human HDAC6, with an inhibition of -1.4% using a commercial peptide substrate and 4.47% using a custom peptide substrate. This compound's diverse inhibitory effects suggest potential applications in both cancer research and antiviral therapeutics..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
别名	exo-IWR 1

化学信息

分子量	409.44
分子式	C₂₅H₁₉N₃O₃
CAS No.	1127442-87-8
Smiles	[H][C@@]12C[C@]([H])(C=C1)[C@@]1([H])C(=O)N(C(=O)[C@@]21[H])c1ccc(cc1)C(=O)Nc1cccc2cccnc12
密度	1.425 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 12 mg/mL (29.31 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4424 mL	12.2118 mL	24.4236 mL	122.1180 mL
5 mM	0.4885 mL	2.4424 mL	4.8847 mL	24.4236 mL
10 mM	0.2442 mL	1.2212 mL	2.4424 mL	12.2118 mL
20 mM	0.1221 mL	0.6106 mL	1.2212 mL	6.1059 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。