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XL413
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很棒纯度: 99.94%
货号 T3352Cas号 1169558-38-6
XL413 是一种口服生物可利用的细胞分裂周期 7 同源物 (CDC7) 激酶抑制剂，具有潜在的抗肿瘤活性，IC50值为 3.4 nM。它对 pMCM 的 EC50值为 118 nM，对 CK2 和 PIM1 的 IC50值分别为 215 和 42 nM。
其他形式的 “XL413”:
XL413
一键复制产品信息 很棒纯度: 99.94%
货号 T3352Cas号 1169558-38-6
XL413 是一种口服生物可利用的细胞分裂周期 7 同源物 (CDC7) 激酶抑制剂，具有潜在的抗肿瘤活性，IC50值为 3.4 nM。它对 pMCM 的 EC50值为 118 nM，对 CK2 和 PIM1 的 IC50值分别为 215 和 42 nM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 453 | 现货 | |
| 5 mg | ¥ 1,080 | 现货 | |
| 10 mg | ¥ 1,530 | 现货 | |
| 25 mg | ¥ 2,920 | 现货 | |
| 50 mg | ¥ 4,320 | 现货 | |
| 100 mg | ¥ 6,160 | 现货 |
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产品介绍
XL413 AI Summary
XL413 shows significant bioactivities, including the inhibition of key enzymes CDC7, PIM1, and CK2alpha, indicated by low IC50 values. It demonstrates antiproliferative effects and induces apoptosis in human Caco2 cells, along with antitumor activity in athymic nude mice xenografted with Caco2 cells, leading to tumor growth inhibition and regression at various dosages. This compound also shows drug uptake in tumor cells and minimal toxicity as indicated by negligible body weight loss at different dosages.
Moreover, XL413 inhibits several cytochrome P450 enzymes, impacting drug metabolism. Its LogD7.4 value of 2.01 suggests a moderate distribution coefficient, and 92.8% plasma protein binding indicates high binding affinity.
In antiviral research, XL413 inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells (47.61% at 10 µM after 48 hours) and in VERO-6 cells, albeit with much lower inhibition percentages. It also inhibits the SARS-CoV-2 3CL-Pro protease at 20 µM by approximately 14%.
Furthermore, XL413 demonstrates inhibition of human HDAC6 enzyme activity, with varying levels of inhibition observed depending on the peptide substrate used in the assay..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. |
| 靶点活性 | CK2:215nM, CDC7:3.4 nM, Pim1:42 nM, pMCM:118 nM(EC50) |
| 分子量 | 289.72 |
| 分子式 | C14H12ClN3O2 |
| CAS No. | 1169558-38-6 |
| Smiles | O=C1C2=C(C=3C(O2)=CC=C(Cl)C3)NC(=N1)[C@@H]4CCCN4 |
| 密度 | 1.69 g/cm3 (Predicted) |
| 颜色 | White |
| 物理性状 | Solid |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | DMSO: 2.9 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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