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Anti-Serpin A5 Antibody (7V96) 是一种 Mouse 抗体,靶向 Serpin A5。Anti-Serpin A5 Antibody (7V96) 可用于 ELISA。
Anti-Serpin A5 Antibody (7V96) 是一种 Mouse 抗体,靶向 Serpin A5。Anti-Serpin A5 Antibody (7V96) 可用于 ELISA。
产品描述 | Anti-Serpin A5 Antibody (7V96) is a Mouse antibody targeting Serpin A5. Anti-Serpin A5 Antibody (7V96) can be used in ELISA. |
Ig Type | Monoclonal Mouse IgG1 |
克隆号 | 7V96 |
交叉反应 | Human |
应用 | ELISA |
推荐剂量 | ELISA: 1:1000-1:2000 |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant human SerpinA5 (rhSerpinA5; Met1-Pro406NP_000615.3). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Serpin A5, also well known as protein C inhibitor (PCI), is a member of the human serpin superfamily that consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, serpinA5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin, and plays a role in the processes of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin. |
偶联 | Unconjugated |
免疫原 | Recombinant Human SerpinA5 protein |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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