Nitromide

Name: Nitromide
Brand: TargetMol
SKU: T0356
Price: 135 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.84%

货号 T0356Cas号 121-81-3

别名 硝米特, 3,5-Dinitrobenzamide, 3, 5-Dinitrobenzamide

Nitromide (3,5-Dinitrobenzamide) 是一种抗寄生虫药。

Nitromide

一键复制产品信息

很棒

纯度: 99.84%

货号 T0356 别名 硝米特, 3,5-Dinitrobenzamide, 3, 5-DinitrobenzamideCas号 121-81-3

Nitromide (3,5-Dinitrobenzamide) 是一种抗寄生虫药。

规格	价格	库存
100 mg	¥ 197	现货
500 mg	¥ 442	现货
1 g	¥ 569	现货
5 g	¥ 1,380	现货
1 mL x 10 mM (in DMSO)	¥ 135	现货

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产品介绍

Nitromide AI Summary

Nitromide exhibits a variety of bioactivities across multiple assays and systems. It enhances the expression of the SMN2 splice variant and functions as both an activator and an inhibitor/substrate of Cytochrome P450 3A4. The compound inhibits HP1-beta Chromodomain interactions with methylated histone tails and displays delayed death inhibition on the malarial parasite plastid under different incubation times. It inhibits several human tumor cell lines (e.g., Renal, Non-Small Cell Lung, Leukemia, Ovarian, Melanoma, CNS, and Colon), and induces DNA re-replication in SW480 colon adenocarcinoma cells. Additionally, it inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) and shows activity in identifying gametocytocidal compounds. The compound also shows efficacy in blocking entry of the Ebola virus and exhibits select antiviral activities against SARS-CoV-2, inhibiting the virus-induced cytotoxicity in Caco-2 and VERO-6 cells. Its inhibitory activity against SARS-CoV-2 3CL-Pro protease is approximately 39.95% at 20µM. Additionally, Nitromide inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells, and shows moderate activity against human BSEP with an IC50 value of 184500 nM. With a LogD7.4 value of 0.81, it has notable bioactivity profiles including HDAC6 inhibition, particularly stronger with a commercial peptide substrate compared to a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nitromide (3,5-Dinitrobenzamide) is an anti-parasitic drug.
别名	硝米特, 3,5-Dinitrobenzamide, 3, 5-Dinitrobenzamide

化学信息

分子量	211.13
分子式	C₇H₅N₃O₅
CAS No.	121-81-3
Smiles	NC(=O)c1cc(cc(c1)[N+]([O-])=O)[N+]([O-])=O
密度	1.601g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 11 mg/mL (52.1 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.47 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7364 mL	23.6821 mL	47.3642 mL	236.8209 mL
5 mM	0.9473 mL	4.7364 mL	9.4728 mL	47.3642 mL
10 mM	0.4736 mL	2.3682 mL	4.7364 mL	23.6821 mL
20 mM	0.2368 mL	1.1841 mL	2.3682 mL	11.8410 mL
50 mM	0.0947 mL	0.4736 mL	0.9473 mL	4.7364 mL