Clopidogrel

Name: Clopidogrel
Brand: TargetMol
SKU: T0182
Price: 298 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.83%

货号 T0182Cas号 113665-84-2

别名 氯吡格雷, SR-25990C, (S)-Clopidogrel

Clopidogrel (SR-25990C) 是一种 P2Y12 受体拮抗剂，可降低血小板聚集，用于抑制冠状动脉疾病、周围血管疾病和脑血管疾病中的血凝块。

Clopidogrel

一键复制产品信息

很棒

纯度: 98.83%

货号 T0182 别名 氯吡格雷, SR-25990C, (S)-ClopidogrelCas号 113665-84-2

Clopidogrel (SR-25990C) 是一种 P2Y12 受体拮抗剂，可降低血小板聚集，用于抑制冠状动脉疾病、周围血管疾病和脑血管疾病中的血凝块。

规格	价格	库存
50 mg	¥ 298	现货
100 mg	¥ 418	现货
500 mg	¥ 997	现货

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产品介绍

Clopidogrel AI Summary

Clopidogrel is a multifaceted bioactive substance demonstrating significant inhibitory, modulatory, and cytotoxic properties across various biological targets. It acts as a potent inhibitor of human recombinant carboxylesterase 1 (CES1) with a Km value of 55700 nM and a pKm value of 4.25. In the field of enzymatic inhibition, it also shows mechanism-based inhibition of cytochrome P450 2B6, with Ki values of 500 nM and 1100 nM and Kinact values of 0.35 min^-1 and 0.15 min^-1, respectively. It has considerable activity against the serotonin transporter (SERT), with an IC50 of 562 nM and a Ki of 299 nM. The compound exhibits noteworthy bioactivity in various assays: - It inhibits the Influenza NS1 protein function with a potency of 19952.6 nM. - It demonstrates delayed death inhibition of the malarial parasite plastid with potencies of 8275.3 nM (96-hour incubation) and 11689.1 nM (48-hour incubation). - It functions as an inhibitor of HP1-beta chromodomain interactions with methylated histone tails with a potency of 89125.1 nM. Furthermore, Clopidogrel exhibits pharmacokinetic properties in Sprague-Dawley rats, with a maximum concentration (Cmax) of 21.53 nM reached at 0.583 hours post-administration, a half-life of 2.48 hours, and an area under the curve (AUC) of 32200 ng.hr.mL^-1. It shows a high clearance rate in human liver microsomes exceeding 300 mL.min^-1.g^-1, indicating rapid metabolism. In antiplatelet and antithrombotic assays, the compound effectively inhibits ADP-induced platelet aggregation in rabbit platelets and demonstrates significant antithrombotic activity in rodent models, reducing thrombus weight by 67% in the FeCl2-induced thrombosis model. Additionally, it prolongs bleeding time in various animal models, indicative of its anticoagulant potential. On the toxicity front, Clopidogrel has shown moderate hepatotoxicity, as evidenced by elevated serum ALT and AST enzyme levels, and significant impacts on hepatotoxicity indices. It also shows intravital toxicity by prolonging mesenteric and cuticle bleeding time in rat models. The compound exhibits broad-spectrum antibacterial activity, particularly against methicillin-resistant Staphylococcus aureus (MRSA) USA300, and antifungal activity against Candida albicans and Cryptococcus neoformans. However, its antiviral activity against SARS-CoV-2 is limited, with low inhibition efficacy. Overall, Clopidogrel’s diverse bioactivities suggest its potential as a valuable candidate in pharmaceutical research while underscoring the necessity for careful evaluation of its pharmacodynamics and toxicological profiles in further studies..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.
别名	氯吡格雷, SR-25990C, (S)-Clopidogrel

化学信息

分子量	321.82
分子式	C₁₆H₁₆ClNO₂S
CAS No.	113665-84-2
Smiles	COC(=O)[C@@H](N1CCc2sccc2C1)c1ccccc1Cl
密度	1.317g/cm3

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 40 mg/mL (124.29 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.21 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1073 mL	15.5366 mL	31.0733 mL	155.3664 mL
5 mM	0.6215 mL	3.1073 mL	6.2147 mL	31.0733 mL
10 mM	0.3107 mL	1.5537 mL	3.1073 mL	15.5366 mL
20 mM	0.1554 mL	0.7768 mL	1.5537 mL	7.7683 mL
50 mM	0.0621 mL	0.3107 mL	0.6215 mL	3.1073 mL
100 mM	0.0311 mL	0.1554 mL	0.3107 mL	1.5537 mL