EML4-ALK kinase inhibitor 1

Name: EML4-ALK kinase inhibitor 1
Brand: TargetMol
SKU: T11184
Price: 882 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.62%

货号 T11184Cas号 1373409-08-5

别名 EML4-ALK kinase inhibitor 1, EML4 ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) 是有效的、具有口服活性的类棘皮细胞微管相关蛋白4-间变性淋巴瘤激酶 (EML4-ALK) 的抑制剂，其 IC50 值为 1 nM。

为众多的药物研发团队赋能，

让新药发现更简单！

EML4-ALK kinase inhibitor 1

一键复制产品信息

很棒

纯度: 99.62%

货号 T11184 别名 EML4-ALK kinase inhibitor 1, EML4 ALK kinase inhibitor 1Cas号 1373409-08-5

规格	价格	库存
1 mg	¥ 882	现货
5 mg	¥ 2,220	现货
10 mg	¥ 3,190	现货
25 mg	¥ 4,960	现货
50 mg	¥ 6,540	现货
100 mg	¥ 8,880	现货
500 mg	¥ 17,700	现货
1 mL x 10 mM (in DMSO)	¥ 2,860	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.62%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

EML4-ALK kinase inhibitor 1 AI Summary

EML4-ALK kinase inhibitor 1 exhibits potent bioactivities, displaying strong inhibition of EML4-fused ALK variant 1 expressed in mouse BAF3 cells, with an IC50 value of 1.0 nM in an HTRF assay. It also demonstrates antiproliferative activity against the same cell line, with an IC50 value of 9.7 nM in an alamar blue assay. In vivo, EML4-ALK kinase inhibitor 1 shows significant antitumor activity, yielding a 62.0% tumor regression in mouse 3T3 cells expressing EML4-fused ALK variant 1 xenografted in Balb/c nude mice, at a 10 mg/kg dose administered orally once daily for 5 days. Additionally, the compound exhibits good permeability at pH 6.5, with a permeability value of 21.0 x 10^-6 cm/s as measured by the PAMPA assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) is a potent oral active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM.
靶点活性	EML4-ALK:1 nM
别名	EML4-ALK kinase inhibitor 1, EML4 ALK kinase inhibitor 1

化学信息

分子量	580.76
分子式	C₃₁H₄₈N₈O₃
CAS No.	1373409-08-5
Smiles	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(OC)c2)nc1N[C@H]1CC[C@@H](CC1)OC
密度	1.24 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 99 mg/mL (170.47 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.61 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7219 mL	8.6094 mL	17.2188 mL	86.0941 mL
5 mM	0.3444 mL	1.7219 mL	3.4438 mL	17.2188 mL
10 mM	0.1722 mL	0.8609 mL	1.7219 mL	8.6094 mL
20 mM	0.0861 mL	0.4305 mL	0.8609 mL	4.3047 mL
50 mM	0.0344 mL	0.1722 mL	0.3444 mL	1.7219 mL
100 mM	0.0172 mL	0.0861 mL	0.1722 mL	0.8609 mL