Name: Methyl-β-cyclodextrin
Brand: TargetMol
SKU: T4072
Price: 235 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

500 mg

¥ 326

In stock

1 g

¥ 395

In stock

1 mL x 10 mM (in DMSO)

¥ 235

In stock

产品介绍

生物活性

产品描述	Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a macrocyclic compound used as a solubilizer for hydrophobic compounds in biological experiments. Methyl-β-cyclodextrin is also a lipid raft inhibitor with cholesterol-lowering activity and potential antitumor activity.
靶点活性	LPS/oxLDL-triggered monocyte-endothelial adhesion and related molecules (signalling pathway):27.66 mM, CHO cellslesterol:14.4 μM, PEL:3.33-4.23 mM.
体外活性	方法：五种原发性渗出性淋巴瘤 (PEL) 细胞系 BCBL-1、BC-1、BC-3、TY-1 和 GTO 用 Methyl-β-cyclodextrin (0-10 mM) 处理 24 h，使用 MTT assay 检测细胞活力。结果：Methyl-β-cyclodextrin 剂量依赖性抑制 PEL 细胞生长，IC50 在 3.33-4.23 mM 之间。[1] 方法：鸡肝癌细胞 LMH 用 Methyl-β-cyclodextrin (10 mM) 处理 1 h，然后在感染 FAdV-4 之前、期间和之后的不同时间点添加胆固醇 (50 µg/mL)，使用 Western Blot 检测靶点蛋白表达水平。结果：当 LMH 细胞在感染前用增加浓度的 Methyl-β-cyclodextrin 预处理时，penton 蛋白水平以剂量依赖的方式降低。[2]
体内活性	方法：为检测体内抗肿瘤活性，将 Methyl-β-cyclodextrin (500 mg/kg) 腹腔注射给携带 PEL 肿瘤 BCBL-1 的 NRJ 小鼠，每天一次，持续二十一天。结果：Methyl-β-cyclodextrin 显著抑制 PEL 细胞的生长和侵袭，没有明显的不良反应。[1] 方法：为研究对胶原蛋白的调节作用，将 Methyl-β-cyclodextrin (1.25-5.0 mg/mouse) 皮内注射给 SKH1 小鼠，每周两次，持续两个月。结果：Methyl-β-cyclodextrin 显示出强大的 COL I 上调活性，导致皮肤厚度增加。[3]
激酶实验	PEL cells are incubated in triplicate in a 96-well microculture plate in the presence of different concentrations of methyl-β-cyclodextrin (0-10 mM) in a final volume of 0.1 mL for 24 h at 37°C. Subsequently, MTT (0.5 mg/mL final concentration) is added to each well. After 3 h of additional incubation, 100 μL of a 0.04 N HCl is added to dissolve the crystals. Absorption values at 570 nm are determined.
细胞实验	PEL cells are incubated in triplicate in a 96-well microculture plate in the presence of different concentrations of methyl-β-cyclodextrin (0-10 mM) in a final volume of 0.1 mL for 24 h at 37°C. Subsequently, MTT (0.5 mg/mL final concentration) is added to each well. After 3 h of additional incubation, 100 μL of a 0.04 N HCl is added to dissolve the crystals. Absorption values at 570 nm are determined[1].
别名	甲基倍他环糊精, 甲基-β-环糊精, Methyl-beta-cyclodextrin, beta-Cyclodextrin methyl ethers

化学信息

分子量	1310(Average)
分子式	C₅₄H₉₄O₃₅
CAS No.	128446-36-6
Smiles	COCC1OC2OC3C(COC)OC(OC4C(COC)OC(OC5C(COC)OC(OC6C(COC)OC(OC7C(COC)OC(OC8C(COC)OC(OC1C(O)C2OC)C(OC)C8O)C(OC)C7O)C(OC)C6O)C(OC)C5O)C(OC)C4O)C(OC)C3O
密度	1.4 g/cm3