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Melperone

Name: Melperone
Brand: TargetMol
SKU: T7421
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.84%

货号 T7421Cas号 3575-80-2

别名 美哌隆

Melperone 是一种丁酰苯，是一种具有睡眠诱导作用的抗精神病试剂，常用于研究精神类疾病。

Melperone

一键复制产品信息

很棒

纯度: 98.84%

货号 T7421 别名 美哌隆Cas号 3575-80-2

Melperone 是一种丁酰苯，是一种具有睡眠诱导作用的抗精神病试剂，常用于研究精神类疾病。

规格	价格	库存
2 mg	¥ 108	现货
5 mg	¥ 153	现货
10 mg	¥ 248	现货
25 mg	¥ 395	现货
50 mg	¥ 548	现货
100 mg	¥ 833	现货
200 mg	¥ 1,230	现货
1 mL x 10 mM (in DMSO)	¥ 172	现货

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实验操作小课堂

常见问题解答

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纯度: 98.84%

颜色: 黄色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Melperone AI Summary

Melperone exhibits a wide range of bioactivities with varying potencies across different assays. It shows significant potency in inhibiting the Menin-MLL interaction in MLL-related leukemias (44668.4 nM) and acts as a delayed death inhibitor of the malarial parasite plastid after a 96-hour incubation (95.3 nM). It demonstrates potencies in promoting Schwann cell viability (40533.4 nM), involvement in a Schwann cell luciferase assay (16136.6 nM), and blocking the entry of Ebola virus with AC50 values of 6309.6 nM and 6.31 µM in different assays. Pharmacokinetically, Melperone shows moderate clearance (46.0 mL·min⁻¹·kg⁻¹), a short half-life (3.9 hours), a moderate mean residence time (5.0 hours), and a moderate volume of distribution at steady state (14.0 L·kg⁻¹) in humans after intravenous administration. The compound exhibits moderate hepatotoxicity, characterized by cytolytic, choleostatic, and mixed liver toxicity, though severe hepatitis and chronic liver conditions have not been linked to it. In antiviral activity assays, Melperone showed mixed results against SARS-CoV-2. It inhibited cytotoxicity in Caco-2 cells by -27.17% at a 10 µM concentration over 48 hours and displayed 16.3% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. However, its IC50 value against SARS-CoV-2 induced cytotoxicity in VERO-6 cells was greater than 20000.0 nM, indicating a relatively weak inhibitory effect. It also demonstrated no significant inhibition of various human transporters (BSEP, MRP2, MRP3, and MRP4) with IC50 values exceeding 133000.0 nM. Additionally, the compound shows minor inhibition rates for human HDAC6, with 18.11% inhibition in one enzymatic assay and -9.44% in another using different peptide substrates. It has bioactivity involving a primary screen assay using NF54 nanoGlo with a Z score of 0.66 and -6.0% inhibition at 2µM over 72 hours. Melperone also interacts with several receptors, including DRD1, DRD3, ADRA2A, HTR1A, and others, with AC50 values from 305.0 nM to 12567.5 nM, showing agonistic activity at HTR2B and ADRA1A receptors (AC50 > 30000.0 nM), and antagonist activity at the TBXA2R receptor (AC50 > 30000.0 nM). These interactions suggest potential effects on neurotransmitter systems and hormone receptors..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Melperone, a butyrophenone tranquillizer, caused bradycardia in vivo and in vitro.
别名	美哌隆

化学信息

分子量	263.35
分子式	C₁₆H₂₂FNO
CAS No.	3575-80-2
Smiles	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1
密度	1.046 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 41.67 mg/mL (158.23 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.59 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7972 mL	18.9861 mL	37.9723 mL	189.8614 mL
5 mM	0.7594 mL	3.7972 mL	7.5945 mL	37.9723 mL
10 mM	0.3797 mL	1.8986 mL	3.7972 mL	18.9861 mL
20 mM	0.1899 mL	0.9493 mL	1.8986 mL	9.4931 mL
50 mM	0.0759 mL	0.3797 mL	0.7594 mL	3.7972 mL
100 mM	0.0380 mL	0.1899 mL	0.3797 mL	1.8986 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Melperone Inhibitor inhibit

Melperone

Melperone

Melperone 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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