ST7612AA1

Name: ST7612AA1
Brand: TargetMol
SKU: T70692
Price: 1300 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.71%

货号 T70692Cas号 1428535-92-5

ST7612AA1 是一种新型有效且可口服的 HDAC 抑制剂，作为作为HIV-1潜伏期再激活剂。ST7612AA1 在体内外实验中低浓度显示出显著的抗肿瘤活性。ST7612AA1 具有潜在的抗癌活性，可用于研究疟疾。

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ST7612AA1

一键复制产品信息

很棒

纯度: 99.71%

货号 T70692Cas号 1428535-92-5

规格	价格	库存
1 mg	¥ 1,300	现货
5 mg	¥ 3,250	现货
10 mg	¥ 4,750	现货
25 mg	¥ 7,480	现货
50 mg	¥ 9,870	现货
100 mg	¥ 13,600	现货
500 mg	¥ 27,300	现货

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纯度: 99.71%

ee: 97.06%

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COA CSFC HNMR LCMS 产品操作手册

产品介绍

ST7612AA1 AI Summary

ST7612AA1 exhibits significant cytotoxicity against human NCI-H460 cells with an IC50 of 66.0 nM and rat L6 cells with an IC50 of 189.0 nM. In addition, it shows antiprotozoan activities against Trypanosoma brucei rhodesiense STIB 900, Trypanosoma cruzi Tulahuen C4, Plasmodium falciparum NF54, and Giardia lamblia G1, with IC50 values of 2510.0 nM, 2100.0 nM, 6570.0 nM, and 8110.0 nM, respectively. The compound also inhibits HDAC-mediated tubulin deacetylation and histone H4 deacetylation in human NCI-H460 cells with IC50 values of 200.0 nM and 5.0 nM, respectively. ST7612AA1 is highly soluble in diluted Solutol HS15 and exhibits high intrinsic clearance in human hepatocytes. Moreover, it shows substantial antitumor activity against various xenografted human cancer cell lines, including HCT116, NCI-H1975, SK-OV-3, MDA-MB-436, and MV4-11, with tumor volume inhibition rates ranging from 35.0% to 89.0% at a dose of 60 mg/kg. Despite its promising antitumor effects, the compound induces toxicity, demonstrated by body weight loss in xenografted mice..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ST7612AA1 is a novel potent and oral HDCA inhibitor that acts as an HIV-1 latency reactivator. ST7612AA1 showed significant antitumor activity at low concentrations in vitro and in vivo. ST7612AA1 has potential anticancer activity and can be used to study malaria.

化学信息

分子量	405.51
分子式	C₂₀H₂₇N₃O₄S
CAS No.	1428535-92-5
Smiles	C(N[C@H](C(NC1=CC=CC=C1)=O)CCCCCSC(C)=O)(=O)[C@@H]2NC(=O)CC2

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (135.63 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4660 mL	12.3302 mL	24.6603 mL	123.3015 mL
5 mM	0.4932 mL	2.4660 mL	4.9321 mL	24.6603 mL
10 mM	0.2466 mL	1.2330 mL	2.4660 mL	12.3302 mL
20 mM	0.1233 mL	0.6165 mL	1.2330 mL	6.1651 mL
50 mM	0.0493 mL	0.2466 mL	0.4932 mL	2.4660 mL
100 mM	0.0247 mL	0.1233 mL	0.2466 mL	1.2330 mL