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DPA-714

Name: DPA-714
Brand: TargetMol
SKU: T15162
Price: 447 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T15162Cas号 958233-07-3 一键复制产品信息纯度: 99.52%

很棒

DPA-714 是高亲和力的移位蛋白配体 (Ki=7 nM)，它结构中有一个氟原子，能够被氟 -18 进行标记，并可通过正电子发射断层成像进行活体成像。它可在各种神经炎症模型及脑肿瘤模型中成功评估炎症的特异性成像。

DPA-714

一键复制产品信息

很棒

纯度: 99.52%

货号 T15162Cas号 958233-07-3

规格	价格	库存
1 mg	¥ 447	现货
5 mg	¥ 1,090	现货
10 mg	¥ 1,630	现货
25 mg	¥ 2,680	现货
50 mg	¥ 3,770	现货
100 mg	¥ 5,080	现货
1 mL x 10 mM (in DMSO)	¥ 1,110	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.52%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

DPA-714 AI Summary

DPA-714 shows high affinity for the translocator protein (TSPO) receptor in various rat tissues, with reported Ki values ranging from 0.91 nM in rat heart membranes to 7.0 nM in rat kidney and brain cortex mitochondrial membranes. This indicates its potential bioactivity as a modulator of TSPO, a receptor involved in cellular functions such as apoptosis, inflammation, and neuroprotection. Despite its strong affinity for TSPO, DPA-714 exhibits very low affinity for the central benzodiazepine receptor (CBR), with Ki values greater than 1000.0 nM in rat cerebral cortex membranes. The compound has moderate lipophilicity, with reported LogP values from 2.12 to 2.89 at pH 7.4-7.5. Metabolic studies show that the compound is subjected to different rates of drug metabolism, with intrinsic clearance values of 68.0 uL/min in human hepatic microsomes, over 1000.0 uL/min in Sprague-Dawley rat hepatic microsomes, and 408.0 uL/min in CD1 mouse hepatic microsomes. It also demonstrates good metabolic stability in rat brain, with less than 3.0% of the parent compound remaining after 30 minutes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM). It is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. [18F]DPA-714 successfully assesses for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.
靶点活性	TSPO:(ki)7 nM

化学信息

分子量	398.47
分子式	C₂₂H₂₇FN₄O₂
CAS No.	958233-07-3
Smiles	CCN(CC)C(=O)Cc1c(nn2c(C)cc(C)nc12)-c1ccc(OCCF)cc1
密度	1.18 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 41.67 mg/mL (104.57 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.02 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5096 mL	12.5480 mL	25.0960 mL	125.4800 mL
5 mM	0.5019 mL	2.5096 mL	5.0192 mL	25.0960 mL
10 mM	0.2510 mL	1.2548 mL	2.5096 mL	12.5480 mL
20 mM	0.1255 mL	0.6274 mL	1.2548 mL	6.2740 mL
50 mM	0.0502 mL	0.2510 mL	0.5019 mL	2.5096 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2548 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。