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AR 231453

Name: AR 231453
Brand: TargetMol
SKU: T8329
Price: 228 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.34%

货号 T8329Cas号 733750-99-7

AR 231453 是一种口服具有活性的、特异性的 GPR119激动剂。它能够刺激细胞增殖，改善胰岛 β 细胞的功能。[1]

为众多的药物研发团队赋能，

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AR 231453

一键复制产品信息

很棒

纯度: 99.34%

货号 T8329Cas号 733750-99-7

AR 231453 是一种口服具有活性的、特异性的 GPR119激动剂。它能够刺激细胞增殖，改善胰岛 β 细胞的功能。[1]

规格	价格	库存
1 mg	¥ 228	现货
2 mg	¥ 326	现货
5 mg	¥ 529	现货
10 mg	¥ 795	现货
25 mg	¥ 1,280	现货
50 mg	¥ 1,850	现货
100 mg	¥ 2,850	现货
1 mL x 10 mM (in DMSO)	¥ 589	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.34%

颜色: 黄色

性状: Solid

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COA LCMS HNMR 产品操作手册

产品介绍

AR 231453 AI Summary

AR 231453 exhibits potent agonist activity at the GPR119 receptor across various human cell lines and animal models, including mice, rats, dogs, and cynomolgus monkeys. It effectively induces dispersion of melatonin-induced pigmentation with EC50 values ranging from 0.4 to 14.0 nM. In particular, it stimulates cAMP production in hamster HIT-T15 cells with an EC50 of 4.7 nM. Several studies confirm its efficacy and potency, such as an EC50 of 0.65 nM in melanophore assays and 102% intrinsic activity relative to AR231453 using the HTRF assay in human GPR119 receptors. Pharmacokinetic data reveal good oral bioavailability, with 12.0% in Sprague-Dawley rats. It achieves a Tmax of 0.5 hours, a Cmax of 9841.16 nM, and a half-life of 3.4 hours in C57BL/6J mice, and a Tmax of 1.0 hour, a Cmax of approximately 250 nM, and a half-life of 1.1 hours in Sprague-Dawley rats. The compound also shows high plasma protein binding, with 98.4% in rat plasma and 99.01% in human plasma, suggesting significant implications for its distribution and pharmacokinetic profile. AR 231453 additionally induces insulin secretion in mouse pancreatic islets and displays 100% efficacy relative to AR231453 in various assays, making it a promising candidate for further research and development..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Azenosertib (ZN-c3) is an orally active, specific GPR119 agonist. Azenosertib (ZN-c3) stimulates cell proliferation and improves pancreatic β-cell function. [1]

化学信息

分子量	505.52
分子式	C₂₁H₂₄FN₇O₅S
CAS No.	733750-99-7
Smiles	N(=O)(=O)C=1C(=NC=NC1NC2=C(F)C=C(S(C)(=O)=O)C=C2)N3CCC(CC3)C4=NC(C(C)C)=NO4
密度	1.421 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10 mg/mL (19.78 mM), Sonication is recommended.

H2O: 60 mg/mL (118.69 mM), Sonication and heating are recommended.

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.9782 mL	9.8908 mL	19.7816 mL	98.9081 mL
5 mM	0.3956 mL	1.9782 mL	3.9563 mL	19.7816 mL
10 mM	0.1978 mL	0.9891 mL	1.9782 mL	9.8908 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0989 mL	0.4945 mL	0.9891 mL	4.9454 mL
50 mM	0.0396 mL	0.1978 mL	0.3956 mL	1.9782 mL
100 mM	0.0198 mL	0.0989 mL	0.1978 mL	0.9891 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。