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BRK inhibitor P21d hydrochloride
Synonyms: BRK inhibitor P21d hydrochloride货号 T39772Cas号 2250025-98-8 一键复制产品信息
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还可以BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BRK inhibitor P21d hydrochloride, serves as a valuable tool for evaluating the efficacy of BRK inhibitors in xenograft breast tumor models, enabling the assessment of their in vivo activity.
BRK inhibitor P21d hydrochloride
一键复制产品信息 还可以货号 T39772Cas号 2250025-98-8
别名 BRK inhibitor P21d hydrochloride
BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BRK inhibitor P21d hydrochloride, serves as a valuable tool for evaluating the efficacy of BRK inhibitors in xenograft breast tumor models, enabling the assessment of their in vivo activity.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 16,700 | 3-6月 | |
| 50 mg | ¥ 25,300 | 3-6月 | |
| 100 mg | ¥ 38,300 | 3-6月 |
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| 产品描述 | BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BRK inhibitor P21d hydrochloride, serves as a valuable tool for evaluating the efficacy of BRK inhibitors in xenograft breast tumor models, enabling the assessment of their in vivo activity. |
| 靶点活性 | Brk:30 nM (IC50), pSAM68:52 nM (IC50), Aurora B:>20 μM (IC50), Lck:>20 μM (IC50) |
| 体外活性 | BRK inhibitor P21d hydrochloride (compound 21d) inhibits Aurora B (IC 50 >20 μM) and Lck (IC 50 >20 μM)[1]. |
| 体内活性 | BRK inhibitor P21d hydrochloride (compound 21d) has much better permeability (CACO-2:314 nm/s) and PK profile (rat, po, 10 mpk, AUC 0–6h =31.1 μM?h,C 6h =3.5 μM)[1]. |
| 别名 | BRK inhibitor P21d hydrochloride |
| 分子量 | 483.93 |
| 分子式 | C23H23ClFN7O2 |
| CAS No. | 2250025-98-8 |
| Smiles | Cl.Fc1cc(ccc1Nc1nc(cn2c(cnc12)-c1cn[nH]c1)C1CC1)C(=O)N1CCOCC1 |
| 密度 | no data available |
| 存储 |
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体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
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