Salicylamide

Name: Salicylamide
Brand: TargetMol
SKU: T0004
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.96%

货号 T0004Cas号 65-45-2

别名 水杨酰胺, Salamide, 2-Hydroxybenzamide

Salicylamide(2-Hydroxybenzamide) 是一种止痛剂和抗热解药剂，是一种微粒体 UDP-葡糖醛酸基转移酶抑制剂。

Salicylamide

一键复制产品信息

很棒

纯度: 99.96%

货号 T0004 别名 水杨酰胺, Salamide, 2-HydroxybenzamideCas号 65-45-2

Salicylamide(2-Hydroxybenzamide) 是一种止痛剂和抗热解药剂，是一种微粒体 UDP-葡糖醛酸基转移酶抑制剂。

规格	价格	库存
1 g	¥ 148	现货
5 g	¥ 179	现货
10 g	¥ 197	现货
1 mL x 10 mM (in DMSO)	¥ 108	现货

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产品介绍

Salicylamide AI Summary

Salicylamide exhibits diverse bioactivities across various biological pathways and assays. It shows weak inhibition of the human androgen receptor with an IC50 value greater than 1000 nM and minimal binding affinity (RBA < 1.0). It also weakly binds to stromelysin (MMP-3) with a dissociation constant (Kd) exceeding 25,000,000 nM. The compound displays no significant inhibition of HIV-1 integrase and shows varied enzyme inhibition profiles, including minimal inhibition of iNOS and multiple MMP enzymes, with no activity against human recombinant UGT2B10 and UGT2B4 enzymes. Additionally, Salicylamide affects locomotor activity in albino mice and exhibits potential for skin permeability (log Kp = -5.31). Within antiviral assays, it demonstrated moderate activity against SARS-CoV-2 with varying degrees of inhibition in different cellular assays. It displays antiproliferative activity against human cell lines and affects numerous biochemical and hematological parameters. The compound also shows significant inhibition of OATP1B3 and OATP1B1 uptake in transfected CHO cells, but weak inhibition of human BSEP activity. Overall, Salicylamide serves as a multi-target molecule with potential implications in different therapeutic areas, including antiviral, enzyme inhibition, and transdermal applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Salicylamide (2-Hydroxybenzamide) is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. In the over-the-counter pain remedies, Salicylamide is used in combination with both aspirin and caffeine.
别名	水杨酰胺, Salamide, 2-Hydroxybenzamide

化学信息

分子量	137.14
分子式	C₇H₇NO₂
CAS No.	65-45-2
Smiles	NC(=O)c1ccccc1O
密度	1.32 g/cm3.;1.308 g/cm3.

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (401.05 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.58 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2918 mL	36.4591 mL	72.9182 mL	364.5909 mL
5 mM	1.4584 mL	7.2918 mL	14.5836 mL	72.9182 mL
10 mM	0.7292 mL	3.6459 mL	7.2918 mL	36.4591 mL
20 mM	0.3646 mL	1.8230 mL	3.6459 mL	18.2295 mL
50 mM	0.1458 mL	0.7292 mL	1.4584 mL	7.2918 mL
100 mM	0.0729 mL	0.3646 mL	0.7292 mL	3.6459 mL