Syk-IN-4

Name: Syk-IN-4
Brand: TargetMol
SKU: T37077
Rating: 4.5 (1 reviews)

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产品编号 T37077

Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, demonstrating an IC50 of 0.31 nM. It targets SYK, which has been identified as a potential therapeutic target for autoimmunity and hematological cancers[1].

Syk-IN-4

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Syk-IN-4

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产品编号 T37077

规格	价格	库存
5 mg	¥ 3,720	待询
10 mg	¥ 6,630	待询
25 mg	¥ 11,300	待询
50 mg	¥ 17,200	待询
100 mg	¥ 26,100	待询
1 mL x 10 mM (in DMSO)	¥ 4,090	待询

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产品介绍

生物活性

产品描述	Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, demonstrating an IC50 of 0.31 nM. It targets SYK, which has been identified as a potential therapeutic target for autoimmunity and hematological cancers[1].
体外活性	Syk-IN-4 is a potent inhibitor of hERG with an IC50 of 3.0 μM[1].Syk-IN-4 inhibits SUDHL-4 and T cell proliferation with GI50s of 0.24 and 2.6 μM, respectively[1].
体内活性	Syk-IN-4 exhibits moderate oral bioavailability (60%) following oral administration (1 mg/kg) in male Hans Wistar rats[1]. Syk-IN-4 exhibits high plasma clearance (151 mL/min/kg) combined with large volumes of distribution (1.0 L/kg respectively) following i.v. administration (0.5 mg/kg) in male Hans Wistar rats[1].

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	DMSO: 62.5 mg/mL (148.99 mM), Sonication is recommended.