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Ceftizoxime

Name: Ceftizoxime
Brand: TargetMol
SKU: T4501
Price: 139 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.91%

货号 T4501Cas号 68401-81-0

别名 头孢唑肟, Epocelin

Ceftizoxime (Epocelin) 是一种强效抗菌剂，它通过干扰细菌细胞壁合成和抑制肽聚糖的交联起作用。它对广谱的 β-内酰胺酶具有高度抗性，并且对多种需氧和厌氧的革兰氏阳性和革兰氏阴性微生物均有效。

Ceftizoxime

一键复制产品信息

很棒

纯度: 99.91%

货号 T4501 别名 头孢唑肟, EpocelinCas号 68401-81-0

规格	价格	库存
5 mg	¥ 139	现货
10 mg	¥ 189	现货
25 mg	¥ 328	现货
50 mg	¥ 463	现货
100 mg	¥ 649	现货
200 mg	¥ 953	现货
1 mL x 10 mM (in DMSO)	¥ 153	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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纯度: 99.91%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Ceftizoxime AI Summary

Ceftizoxime demonstrates a range of bioactivities and pharmacokinetic properties. It acts as a potent antimicrobial agent with in vitro minimum inhibitory concentrations (MIC) values as low as 0.025 µg/mL against Escherichia coli, Klebsiella pneumonia, and Proteus mirabilis. It also shows activity against other bacteria like Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Serratia marcescens with MIC values from 6.25 to 50.0 µg/mL. Additionally, it exhibits activity against various strains of Staphylococcus, including oxacillin-resistant and methicillin-resistant strains, with MIC values ranging from 0.12 to 800.0 µg/mL. Pharmacokinetically, Ceftizoxime has a plasma half-life of approximately 0.25 hours in rats, 0.7333 hours in monkeys, and 1.6 hours in humans after intravenous administration. It shows a total body clearance (CL) of 2.1 mL/min/kg and a renal clearance (CL_renal) of 1.68 mL/min/kg in humans. The compound has good pharmacokinetic properties with a half-life ranging from 0.22 to 0.23 hours, and a high fAUC/MIC ratio of 1000.0, indicating its potential as an effective antimicrobial agent. Ceftizoxime also shows significant liver enzyme activity, increasing levels of alkaline phosphatase, SGOT, SGPT, and LDH, although it has no observed bioactivities related to drug-induced liver injury according to the Drug Induced Liver Injury Prediction System (DILIps). The compound is a substrate for the human MRP4 transporter, with a Km value of 18000.0 nM, and exhibits inhibitory activity against the human HDAC6 enzyme, indicating potential as an HDAC6 inhibitor. It also exhibits bioactivity as a binding agent to multiple receptors and shows various activities including agonist and antagonist actions with high AC50 values above 17000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ceftizoxime (Epocelin) is a cephalosporin-based, potent antibacterial agent which can be administered intravenously or by suppository. It is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.
别名	头孢唑肟, Epocelin

化学信息

分子量	383.40
分子式	C₁₃H₁₃N₅O₅S₂
CAS No.	68401-81-0
Smiles	O=C1N2[C@@]([C@@H]1NC(/C(=N\OC)/C3=CSC(N)=N3)=O)(SCC=C2C(O)=O)[H]
密度	1.89 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25.00 mg/mL (65.21 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (5.22 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6082 mL	13.0412 mL	26.0824 mL	130.4121 mL
5 mM	0.5216 mL	2.6082 mL	5.2165 mL	26.0824 mL
10 mM	0.2608 mL	1.3041 mL	2.6082 mL	13.0412 mL
20 mM	0.1304 mL	0.6521 mL	1.3041 mL	6.5206 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL	2.6082 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit Ceftizoxime Bacterial Antibiotic Antibacterial

Ceftizoxime

Ceftizoxime

Ceftizoxime 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

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