规格

价格

库存

数量

1 mg

¥ 523

现货

5 mg

¥ 1,300

现货

10 mg

¥ 2,080

现货

25 mg

¥ 3,760

现货

50 mg

¥ 5,170

现货

100 mg

¥ 6,960

现货

200 mg

¥ 9,370

现货

1 mL x 10 mM (in DMSO)

¥ 1,490

现货

生物活性

产品描述	HPK1-IN-2 (Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2) is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1; IC50<0.05 μΜ). It also inhibits Lck (0.05 μΜ
靶点活性	FLT3:<0.05 µΜ , HPK1:IC50<0.05 µΜ, Lck:0.05 µΜ
体外活性	In a-CD3 stimulated Jurkat E6. 1 cells, HPK1-IN-2 inhibits SLP76 serine 376 phosphorylation and ERK1/2 T202/Y204 phosphorylation with IC50 values of 0.3-1 μΜ and >3μΜ, respectively.
体内活性	HPK1-IN-2 (75-150 mg/kg; oral gavage; daily; for 21 days) treatment shows a dose-dependently tumor growth inhibition, with 75 mg/kg and 150 mg/kg QD inhibiting tumour growth by 44% and 64%, respectively
别名	Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2, HPK1-IN-2

化学信息

分子量	380.47
分子式	C₁₉H₂₀N₆OS
CAS No.	2056122-11-1
Smiles	NC1=C(C=2NC=3C(N2)=CC=C(C3)N4CCN(C)CC4)C(=O)NC5=C1C=CS5
密度	1.418 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 25 mg/mL (65.71 mM), Sonication is recommended.

溶液配制表

H2O