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Bromperidol

Name: Bromperidol
Brand: TargetMol
SKU: T14830
Price: 219 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.89%

货号 T14830Cas号 10457-90-6

别名 溴哌利多, R-11333

Bromperidol (R-11333) 是一种苯丁酮衍生物，是一种强效长效精神安定药。它被用作治疗精神分裂症的抗精神病药。

Bromperidol

一键复制产品信息

很棒

纯度: 99.89%

货号 T14830 别名 溴哌利多, R-11333Cas号 10457-90-6

Bromperidol (R-11333) 是一种苯丁酮衍生物，是一种强效长效精神安定药。它被用作治疗精神分裂症的抗精神病药。

规格	价格	库存
5 mg	¥ 219	现货
10 mg	¥ 370	现货
25 mg	¥ 713	现货
1 mL x 10 mM (in DMSO)	¥ 262	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.89%

颜色: 白色

性状: Solid

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资源下载:

COA HPLC LCMS HNMR 产品操作手册

产品介绍

Bromperidol AI Summary

Bromperidol is a multifaceted bioactive compound with wide-ranging pharmacological effects and tissue distribution profiles. After intravenous administration in rats at a dose of 0.2 mg/kg, it exhibits significant distribution across multiple organs, including the brain, liver, kidney, lungs, and spleen, persisting up to 8 hours post-administration, with the highest initial concentration observed in the lungs. The compound shows prominent inhibitory activity against Acid Sphingomyelinase (ASM) in rat PC12 cells and human tyrosyl-DNA phosphodiesterase 1, alongside several cytochrome P450 enzymes, TGF-b, and AmpC Beta-Lactamase, reflecting its diverse bioactivity spectrum. Moreover, Bromperidol displays antiviral properties, inhibiting SARS-CoV-2-induced cytotoxicity in various cell lines and showing partial inhibition of the SARS-CoV-2 3CL-Pro protease. It also demonstrates antifungal activity with synergistic effects when combined with specific antifungal drugs. While exhibiting moderate liver toxicity, including hepatotoxicity, it lacks evidence of causing other types of liver damage such as steatosis or tumor formation. In terms of antibacterial properties, the compound inhibits Mycobacterium tuberculosis Eis enzyme and potentiates kanamycin-induced activity against Mycobacterium tuberculosis, although it shows limited activity against other mycobacterial strains. Additionally, it binds multiple human receptors and transporters, contributing to its wide-ranging pharmacological effects. In conclusion, Bromperidol represents a versatile bioactive agent with significant potential across multiple therapeutic areas, though its moderate liver toxicity and variable activity across different pathogens necessitate further investigation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Bromperidol (R-11333) is a butyrophenone derivative and it is a potent and long-acting neuroleptic. Which is used as an antipsychotic in the treatment of schizophrenia.
别名	溴哌利多, R-11333

化学信息

分子量	420.32
分子式	C₂₁H₂₃BrFNO₂
CAS No.	10457-90-6
Smiles	OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Br)cc1
密度	1.3109 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (118.96 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.76 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3791 mL	11.8957 mL	23.7914 mL	118.9570 mL
5 mM	0.4758 mL	2.3791 mL	4.7583 mL	23.7914 mL
10 mM	0.2379 mL	1.1896 mL	2.3791 mL	11.8957 mL
20 mM	0.1190 mL	0.5948 mL	1.1896 mL	5.9478 mL
50 mM	0.0476 mL	0.2379 mL	0.4758 mL	2.3791 mL
100 mM	0.0238 mL	0.1190 mL	0.2379 mL	1.1896 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Spectinomycin schizophrenia R11333 R 11333 mycobacteria Inhibitor inhibit Dopamine Receptor Bromperidol Bacterial antipsychotic antibacterial 5HTReceptor 5-HT Receptor 5HT Receptor

Bromperidol

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体内实验配液计算器

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