7ACC2

Name: 7ACC2
Brand: TargetMol
SKU: T1768
Price: 343 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.66%

货号 T1768Cas号 1472624-85-3

7ACC2 是单羧酸盐转运蛋白抑制剂，IC50为 11 nM。它还是线粒体丙酮酸转运的有效抑制剂，可抑制乳酸涌入，通过抑制乳酸通量来发挥抗癌作用。

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7ACC2

一键复制产品信息

很棒

纯度: 99.66%

货号 T1768Cas号 1472624-85-3

7ACC2 是单羧酸盐转运蛋白抑制剂，IC50为 11 nM。它还是线粒体丙酮酸转运的有效抑制剂，可抑制乳酸涌入，通过抑制乳酸通量来发挥抗癌作用。

规格	价格	库存
1 mg	¥ 343	现货
5 mg	¥ 745	现货
10 mg	¥ 1,230	现货
25 mg	¥ 2,280	现货
50 mg	¥ 3,530	现货
100 mg	¥ 4,970	现货
200 mg	¥ 7,130	现货
1 mL x 10 mM (in DMSO)	¥ 845	现货

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产品介绍

7ACC2 AI Summary

7ACC2 shows bioactivities related to lactate uptake, metabolism, and solubility. It inhibits MCT4-mediated lactate uptake in human SiHa cells, with IC50 values of 10.0 nM after 12 minutes and 59.0 nM after 24 hours. Additionally, it demonstrates cytotoxicity against human SiHa cells with an EC50 value of 220.0 nM. This compound exhibits favorable stability in various fluids and biological systems, such as simulated gastric fluid, simulated intestinal fluid, mouse plasma, and human plasma. It also has a relatively long half-life in both mouse and human liver microsomes. Furthermore, 7ACC2 boasts a high aqueous solubility of 58000.0 nM in PBS buffer at pH 7.4..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
靶点活性	MCT:11 nM

化学信息

分子量	309.32
分子式	C₁₈H₁₅NO₄
CAS No.	1472624-85-3
Smiles	CN(Cc1ccccc1)c1ccc2cc(C(O)=O)c(=O)oc2c1
密度	1.368 g/cm3 (Predicted)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 35.71 mg/mL (115.45 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2329 mL	16.1645 mL	32.3290 mL	161.6449 mL
5 mM	0.6466 mL	3.2329 mL	6.4658 mL	32.3290 mL
10 mM	0.3233 mL	1.6164 mL	3.2329 mL	16.1645 mL
20 mM	0.1616 mL	0.8082 mL	1.6164 mL	8.0822 mL
50 mM	0.0647 mL	0.3233 mL	0.6466 mL	3.2329 mL
100 mM	0.0323 mL	0.1616 mL	0.3233 mL	1.6164 mL