Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SU056 是一种 YB-1 抑制剂,可以抑制与其相关的下游蛋白质和通路。SU056 可以诱导卵巢癌细胞周期停滞、凋亡 (apoptosis),并抑制癌细胞迁移。SU056 可增强紫杉醇的细胞毒性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 222 | 现货 | ||
5 mg | ¥ 493 | 现货 | ||
10 mg | ¥ 798 | 现货 | ||
25 mg | ¥ 1,570 | 现货 | ||
50 mg | ¥ 2,380 | 现货 | ||
100 mg | ¥ 3,550 | 现货 |
产品描述 | SU056 is a YB-1 inhibitor. SU056 interacts with YB-1 and inhibits and downstream proteins and pathways. SU056 can induce cell-cycle arrest, apoptosis, and inhibit cell migration in ovarian cancer cells. |
体外活性 | SU056 ( 0-10 μ M, 48 hours) inhibits the growth of OVCAR3/4/5/8, SKOV3, and ID8 cells. SU056 (1 μ M, 5-8 days) inhibits colony formation in OVCAR-8 and ID8 cells in a dose-dependent manner. SU056 (1-5 μ M, 6 hours) blocks OVCAR8, SKOV3 and ID8 cells in sub G1 phase and G1 phase phase. SU056 (0-1 μ M, 12 hours) inhibits migration of OVCAR8, SKOV3 and ID8 cells. SU056 (0-5 μ M, 24 hours) induce apoptosis of OVCAR8, SKOV3, and ID8 cells. SU056 (1-5 μ M, 12 h) inhibits the expression of YB-1, TMSB10, SUMO2, and PMSB2 proteins in OVCAR8 cells. SU056 (0.1, 0.5, and 1 μ M. 48 hours) enhances the cytotoxic effect of paclitaxel (0.1, 0.5, and 1 nM) [1]. |
体内活性 | SU056 (20 mg/kg, intraperitoneal injection) inhibits tumor growth in mice implanted with ID8 cells. SU056 (10 mg/kg, intraperitoneal injection, daily) combined with paclitaxel (5 mg/kg, weekly, intraperitoneal injection) inhibits tumor growth in immunodeficient mice implanted with ovarian cancer cells (OVCAR8), and the effect is more significant than that of single administration [1]. |
分子量 | 369.34 |
分子式 | C20H16FNO5 |
CAS No. | 2376580-08-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (121.8 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7075 mL | 13.5377 mL | 27.0753 mL | 67.6883 mL |
5 mM | 0.5415 mL | 2.7075 mL | 5.4151 mL | 13.5377 mL | |
10 mM | 0.2708 mL | 1.3538 mL | 2.7075 mL | 6.7688 mL | |
20 mM | 0.1354 mL | 0.6769 mL | 1.3538 mL | 3.3844 mL | |
50 mM | 0.0542 mL | 0.2708 mL | 0.5415 mL | 1.3538 mL | |
100 mM | 0.0271 mL | 0.1354 mL | 0.2708 mL | 0.6769 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SU056 2376580-08-2 Others SU-056 SU 056 1,3Dioxolo[4,5g]furo[3,4b]quinolin8(5H)one,9(3fluorophenyl)6,9dihydro5(2hydroxyethyl) Inhibitor inhibitor inhibit