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Vincamine

Name: Vincamine
Brand: TargetMol
SKU: T1286
Price: 163 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.96%

货号 T1286Cas号 1617-90-9

别名 长春胺, Perval, Oxybral, Novicet, Equipur, Devincan, Angiopac

Vincamine (Perval) 是从长春花中提取的单萜类吲哚生物碱，可作为外周血管扩张剂，对脑微血管循环有选择性的血管调节作用。它可改善体内葡萄糖稳态，对 2 型糖尿病具有研究潜力。它是GPR40激动剂，通过改善 β 细胞功能障碍和促进葡萄糖刺激型胰岛素分泌发挥 β 细胞保护作用。

Vincamine

一键复制产品信息

很棒

纯度: 98.96%

货号 T1286 别名 长春胺, Perval, Oxybral, Novicet, Equipur, Devincan, AngiopacCas号 1617-90-9

规格	价格	库存
100 mg	¥ 163	现货
500 mg	¥ 328	现货
1 g	¥ 496	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 98.96%

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资源下载:

COA HNMR HPLC LCMS 产品操作手册

产品介绍

生物活性

产品描述	Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.
别名	长春胺, Perval, Oxybral, Novicet, Equipur, Devincan, Angiopac

化学信息

分子量	354.44
分子式	C₂₁H₂₆N₂O₃
CAS No.	1617-90-9
Smiles	CCC12CCCN3CCC4=C(C13)N(C1=CC=CC=C41)C(O)(C2)C(=O)OC
密度	1.1640 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 1 mg/mL (2.82 mM), Sonication and heating are recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.82 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8214 mL	14.1068 mL	28.2135 mL	141.0676 mL

TCMIP相关数据

中药材来源及性味归经

中药材名称	中药材拉丁名	性	味	归经
长春花	Catharanthus roseus(L.)G. Don, Catharanthus roseus(L.)G. Don. cv. Flavus	寒	苦	肝, 肾
大长春花	Catharathus roseus (L.) G.Don	寒	苦	肝, 肾

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Vincamine exhibits a broad spectrum of biological activities. In hypoxia tests, it induced the first gasps in 0.04083 hours after intraperitoneal administration of 20 mg/kg. It demonstrates antimelanogenic activity by reducing intracellular melanin levels in mouse B16 cells, with an IC50 value of 68900.0 nM over 4 days, achieving less than 50% melanin reduction. The compound induces genotoxicity and inhibits ELG1-dependent DNA repair in human embryonic kidney cells at potencies of 16353.5 nM and 14575.0 nM, respectively. It acts as a delayed death inhibitor for the malarial parasite plastid with potencies of 11689.1 nM and 13115.4 nM and shows antagonistic activity towards receptors responsible for Fibrous Dysplasia/McCune-Albright Syndrome with a potency of 31622.8 nM. Additionally, it blocks Ebola virus entry with an AC50 of 8912.5 nM and exhibits high metabolic clearance in human liver microsomes at 66.0 mL·min-1·g-1. In enzyme inhibition assays, Vincamine inhibits electric eel AChE and horse BChE at 7.29% and 3.22%, respectively, at 2 mg/ml. It significantly inhibits fluorescent sodium uptake in OATP1B3 and OATP1B1 transfected cells by 88.88% and 72.87% at 10 µM. It has minimal impact on Vero E6 cell viability when infected with SARS-CoV-2 (inhibition index of 0.1041) but exhibits moderate antiviral activity with IC50 values above 20000.0 nM and 19952.62 nM. The compound also shows inhibitory effects on beta-arrestin 2 recruitment by multiple human receptors, and exhibits cytoprotective activity against STZ-induced apoptosis in rat INS-1 832/13 cells with 63.0% inhibition at 20 µM. Vincamine modulates various cellular targets, inhibiting human KCNH2 (AC50 = 460.0 nM) and displaying activity as both agonist and antagonist on human ADRA1A, CHRM1, TBXA2R, and HTR2B. For other targets like DRD1, SLC6A3, and others, it shows high binding without significant activity within the tested concentration range, maintaining AC50 values above 30000.0 nM. These multifaceted bioactivities highlight its potential for diverse pharmacological applications and necessitate further investigation to elucidate its full therapeutic potential..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl