首页工具

Safironil

产品编号 T67961 CAS 134377-69-8

safironil 是一种新型抗纤维化化合物，是胶原蛋白合成的竞争性抑制剂。safironil 在体外实验中对由胶原蛋白I mRNA 或平滑肌α-actin 水平监测的成纤维细胞的激活，以及由I 型和III 型胶原蛋白和层粘连蛋白生产判断的纤维生成有抑制作用。safironil 在不改变总羟脯氨酸的情况下对肝脏肉芽肿的大小没有影响，但通过增加III 型和减少I 型胶原的沉积改变了纤维化的模式。

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Safironil, CAS 134377-69-8

规格	价格/CNY	货期
1 mg	￥ 680	现货
5 mg	￥ 1,600	现货
10 mg	￥ 2,390	现货
25 mg	￥ 3,960	现货
50 mg	￥ 5,760	现货
100 mg	￥ 7,860	现货
500 mg	￥ 15,800	现货
1 mL * 10 mM (in DMSO)	￥ 1,490	现货

大包装超大折扣，点击咨询

选择批次

纯度: 99.51%

更多批次查询请联系客服

生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin levels, and fibrogenesis as judged by type I and type III collagen and laminin production. safironil had no effect on the size of liver granulomas without altering total hydroxyproline, but altered the pattern of fibrosis by increasing type III and decreasing type I collagen deposition.
体外活性	HOE 77, Safironil, and S 4682 are inhibitors of prolyl 4-hydroxylase, which is essential for thecollagen formation. Although HOE 77, Safironil, and S 4682 seem to work by inhibiting HSC activation, further studies will be required before their clinical application. alpha-Tocopherol, retinyl palmitate, and silybinin reduce lipid peroxidation and attenuate HSC activation in experimental models.[2]
体内活性	The present studies evaluate the mechanism of action of two novel antifibrotic compounds, HOE 077 and Safironil, which were designed as competitive inhibitors of collagen protein synthesis. Stellate cell activation, rather than collagen synthesis, proved to be the target of both HOE 077 and Safironil in the intact liver. In culture, the drugs not only prevented the activation of stellate cells but also accelerated their deactivation. They were no more effective in co-cultures containing hepatocytes than in pure stellate cell cultures, indicating that metabolic conversion of HOE 077 was not required. Interestingly, the response of cells from females was greater than that of male cells, leading to the conclusion that stellate activation is sexually dimorphic. This finding may be relevant to the observation that fibrosis in chronic viral hepatitis progresses less rapidly and that hepatocellular carcinoma is less frequent in females than in males.[1]

分子量	309.36
分子式	C15H23N3O4
CAS No.	134377-69-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 30 mg/mL (96.97 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2325 mL	16.1624 mL	32.3248 mL	80.812 mL
	5 mM	0.6465 mL	3.2325 mL	6.465 mL	16.1624 mL
	10 mM	0.3232 mL	1.6162 mL	3.2325 mL	8.0812 mL
	20 mM	0.1616 mL	0.8081 mL	1.6162 mL	4.0406 mL
	50 mM	0.0646 mL	0.3232 mL	0.6465 mL	1.6162 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Wang YJ, et al. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol. 1998;152(1):279-287. 2. Shimizu I. Antifibrogenic therapies in chronic HCV infection. Curr Drug Targets Infect Disord. 2001;1(2):227-240.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +