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CCR

CCR

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T28072 MLN-3897
化合物MLN-3897
1010731-97-1 98%
MLN-3897 是一种具有口服活性的 CCR1 拮抗剂,对于 125I-MIP-1α 与 THP-1 细胞膜的结合,Ki 为 2.3 nM。 MLN-3897 抑制 Akt 信号转导和 MM 细胞存活和增殖。
T12419L PF-04634817
化合物 T12419L
1228111-63-4 98%
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
T10756 Cenicriviroc Mesylate
化合物 T10756
497223-28-6 98%
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
TN2951 3-(hydroxymethyl)cyclopentanone
化合物 TN2951
113681-11-1 98%
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
T10710 CCR1 antagonist 9
化合物 T10710
1220026-26-5 98%
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
T11521 GW 766994
化合物 T11521
408303-43-5 98%
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
T11472L Molibresib besylate
化合物 T11472L
1895049-20-3 98%
Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
TQ0182 MK-0812
化合物MK-0812
624733-88-6 98%
MK-0812 is an effective and specific CCR2 antagonist.
T14373 AZD2423
化合物 T14373
1229603-37-5 98%
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
T17274 YM022
化合物 T17274
145084-28-2 98%
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
TN3119 5-Hydroxy-7,8-dimethoxyflavanone
5-羟基-7,8-二甲氧基黄烷酮
113981-49-0 98%
5-Hydroxy-7,8-dimethoxyflavanone 是从穿心莲叶和根中分离出来的,具有抗炎活性。
T10711 CCR2 antagonist 1
化合物 T10711
1683534-96-4 98%
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T12076L ML218
化合物 T12076L
1346233-68-8 98%
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
T14307 Aplaviroc
化合物 T14307
461443-59-4 98%
Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
T10709 CCR1 antagonist 7
化合物 T10709
2446154-74-9 98%
CCR1 antagonist 7 (compound 16r) 是CCR1的拮抗剂,IC50值为 4 nM。
T11704 JAK-IN-3
化合物 T11704
1400876-94-9 98%
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T14899 CCR1 antagonist 8
化合物 T14899
1295298-26-8 98%
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
T10714 CCR5 antagonist 1
化合物 T10714
716354-86-8 98%
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T2386 Pirfenidone
吡非尼酮
53179-13-8 98%
Pirfenidone 是一种抗纤维化剂,可减弱纤维细胞中CCL2和CCL12的产生。它可抑制细胞生长,并能降低人胶质瘤细胞系中的TGF-β2蛋白水平,具有抗炎活性。
T16111 ML604086
化合物ML604086
850330-18-6 98%
ML604086 是选择性CCR8抑制剂,抑制循环T 细胞上 CCL1 与 CCR8 结合,还抑制 CCL1 介导的趋化性并提高细胞内 Ca2 浓度。
MLN-3897
T28072
MLN-3897 是一种具有口服活性的 CCR1 拮抗剂,对于 125I-MIP-1α 与 THP-1 细胞膜的结合,Ki 为 2.3 nM。 MLN-3897 抑制 Akt 信号转导和 MM 细胞存活和增殖。
PF-04634817
T12419L
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
Cenicriviroc Mesylate
T10756
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
3-(hydroxymethyl)cyclopentanone
TN2951
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
CCR1 antagonist 9
T10710
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
GW 766994
T11521
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
Molibresib besylate
T11472L
Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
MK-0812
TQ0182
MK-0812 is an effective and specific CCR2 antagonist.
AZD2423
T14373
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
YM022
T17274
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
5-Hydroxy-7,8-dimethoxyflavanone
TN3119
5-Hydroxy-7,8-dimethoxyflavanone 是从穿心莲叶和根中分离出来的,具有抗炎活性。
CCR2 antagonist 1
T10711
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
ML218
T12076L
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
Aplaviroc
T14307
Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
CCR1 antagonist 7
T10709
CCR1 antagonist 7 (compound 16r) 是CCR1的拮抗剂,IC50值为 4 nM。
JAK-IN-3
T11704
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
CCR1 antagonist 8
T14899
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
CCR5 antagonist 1
T10714
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
Pirfenidone
T2386
Pirfenidone 是一种抗纤维化剂,可减弱纤维细胞中CCL2和CCL12的产生。它可抑制细胞生长,并能降低人胶质瘤细胞系中的TGF-β2蛋白水平,具有抗炎活性。
ML604086
T16111
ML604086 是选择性CCR8抑制剂,抑制循环T 细胞上 CCL1 与 CCR8 结合,还抑制 CCL1 介导的趋化性并提高细胞内 Ca2 浓度。
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