CCR

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

Cat. No.	Product Name	CAS No.	Purity
T28072	MLN-3897 化合物MLN-3897	1010731-97-1	98%
T28072	MLN-3897 是一种具有口服活性的 CCR1 拮抗剂，对于 125I-MIP-1α 与 THP-1 细胞膜的结合，Ki 为 2.3 nM。 MLN-3897 抑制 Akt 信号转导和 MM 细胞存活和增殖。
T12419L	PF-04634817 化合物 T12419L	1228111-63-4	98%
T12419L	PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
T10756	Cenicriviroc Mesylate 化合物 T10756	497223-28-6	98%
T10756	Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
TN2951	3-(hydroxymethyl)cyclopentanone 化合物 TN2951	113681-11-1	98%
TN2951	3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
T10710	CCR1 antagonist 9 化合物 T10710	1220026-26-5	98%
T10710	CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
T11521	GW 766994 化合物 T11521	408303-43-5	98%
T11521	GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
T11472L	Molibresib besylate 化合物 T11472L	1895049-20-3	98%
T11472L	Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
TQ0182	MK-0812 化合物MK-0812	624733-88-6	98%
TQ0182	MK-0812 is an effective and specific CCR2 antagonist.
T14373	AZD2423 化合物 T14373	1229603-37-5	98%
T14373	AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
T17274	YM022 化合物 T17274	145084-28-2	98%
T17274	YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
TN3119	5-Hydroxy-7,8-dimethoxyflavanone 5-羟基-7,8-二甲氧基黄烷酮	113981-49-0	98%
TN3119	5-Hydroxy-7,8-dimethoxyflavanone 是从穿心莲叶和根中分离出来的，具有抗炎活性。
T10711	CCR2 antagonist 1 化合物 T10711	1683534-96-4	98%
T10711	CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T12076L	ML218 化合物 T12076L	1346233-68-8	98%
T12076L	ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
T14307	Aplaviroc 化合物 T14307	461443-59-4	98%
T14307	Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
T10709	CCR1 antagonist 7 化合物 T10709	2446154-74-9	98%
T10709	CCR1 antagonist 7 (compound 16r) 是CCR1的拮抗剂，IC50值为 4 nM。
T11704	JAK-IN-3 化合物 T11704	1400876-94-9	98%
T11704	JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T14899	CCR1 antagonist 8 化合物 T14899	1295298-26-8	98%
T14899	CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
T10714	CCR5 antagonist 1 化合物 T10714	716354-86-8	98%
T10714	CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T2386	Pirfenidone 吡非尼酮	53179-13-8	98%
T2386	Pirfenidone 是一种抗纤维化剂，可减弱纤维细胞中CCL2和CCL12的产生。它可抑制细胞生长，并能降低人胶质瘤细胞系中的TGF-β2蛋白水平，具有抗炎活性。
T16111	ML604086 化合物ML604086	850330-18-6	98%
T16111	ML604086 是选择性CCR8抑制剂，抑制循环T 细胞上 CCL1 与 CCR8 结合，还抑制 CCL1 介导的趋化性并提高细胞内 Ca2 浓度。