alpha-Naphthoflavone

Name: alpha-Naphthoflavone
Brand: TargetMol
SKU: T2O2744
Price: 278 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.27%

货号 T2O2744Cas号 604-59-1

别名 苯并黄素；α-萘黄酮；7,8-苯并黄酮, α-萘黄酮, 7,8-benzoflavone

alpha-Naphthoflavone (7,8-benzoflavone) 是合成的黄酮类化合物，是一种竞争性芳香酶抑制剂，其IC50=0.5 μM，Ki=0.2 μM。

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alpha-Naphthoflavone

一键复制产品信息

很棒

纯度: 99.27%

货号 T2O2744 别名 苯并黄素；α-萘黄酮；7,8-苯并黄酮, α-萘黄酮, 7,8-benzoflavoneCas号 604-59-1

alpha-Naphthoflavone (7,8-benzoflavone) 是合成的黄酮类化合物，是一种竞争性芳香酶抑制剂，其IC50=0.5 μM，Ki=0.2 μM。

规格	价格	库存
5 mg	¥ 278	现货
10 mg	¥ 393	现货
25 mg	¥ 659	现货
50 mg	¥ 978	现货
100 mg	¥ 1,470	现货
500 mg	¥ 4,150	待询
1 mL x 10 mM (in DMSO)	¥ 293	现货

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产品介绍

alpha-Naphthoflavone AI Summary

alpha-Naphthoflavone exhibits diverse bioactivities across multiple biochemical and physiological pathways. It demonstrates potent inhibitory effects on several cytochrome P450 enzymes, particularly CYP1A1, CYP1A2, and CYP1B1, with IC50 values ranging from 5.0 nM to 60.0 nM. The compound shows significant enzyme inhibition in human liver microsomes and recombinant systems, indicating a strong interaction with these enzymes involved in drug metabolism. In addition to its effects on cytochrome P450 enzymes, alpha-Naphthoflavone inhibits human recombinant CYP1A2 activity with varying degrees of potency, demonstrated by IC50 values in different assay formats, some as low as 2.0 nM. It also inhibits CYP19 (aromatase) with an IC50 of 70.0 nM and shows interactions with various adenosine receptors, including moderate affinity for A1 and A2A receptors, and significant displacement activity at the A3 receptor. The compound exhibits additional inhibitory activities, including: - CYP1B1 in TCDD-stimulated human MCF7 cells, reversing anticancer drug resistance. - DNA-dependent protein kinase in HeLa cells. - Cholesterol esterase with an IC50 of 47.8 nM. - Thromboxane synthetase, PDE4 and PDE5, and transport proteins like p-glycoprotein, MRP1, and BCRP. Moreover, alpha-Naphthoflavone has shown antioxidant activity, inhibition of TCDD-induced EROD activity, and suppression of NF-kappaB activation in HCT116 cells. It exhibits differential effects on cell viability across various cell types, affecting growth rates differently in HEK293T, U2OS, and human fibroblast cells, indicating potential applications in cell growth modulation. The compound's broad spectrum of bioactivities suggests its potential therapeutic implications in enzyme inhibition, receptor interaction, and modulation of metabolic and signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.
靶点活性	Aromatase:5 nM(Ki)
别名	苯并黄素；α-萘黄酮；7,8-苯并黄酮, α-萘黄酮, 7,8-benzoflavone

化学信息

分子量	272.3
分子式	C₁₉H₁₂O₂
CAS No.	604-59-1
Smiles	O=C1C=C(OC2=C1C=CC1=C2C=CC=C1)C1=CC=CC=C1
密度	1.1382 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 9 mg/mL (33.05 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6724 mL	18.3621 mL	36.7242 mL	183.6210 mL
5 mM	0.7345 mL	3.6724 mL	7.3448 mL	36.7242 mL
10 mM	0.3672 mL	1.8362 mL	3.6724 mL	18.3621 mL
20 mM	0.1836 mL	0.9181 mL	1.8362 mL	9.1811 mL