规格

价格

库存

数量

1 mg

¥ 357

现货

5 mg

¥ 892

现货

10 mg

¥ 1,450

现货

25 mg

¥ 2,650

现货

50 mg

¥ 3,790

现货

100 mg

¥ 5,430

现货

1 mL x 10 mM (in DMSO)

¥ 787

现货

生物活性

产品描述	GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.
靶点活性	β-glucuronidase:0.7 nM
体外活性	GSK-626616 (serum-deprived HeLa cells) reduces EGF-induced phosphorylation of PRAS40 at Thr246. GSK-626616 enhances the binding of PRAS40 to mTORC1[2]. GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells. GSK-626616 reduces the phosphorylation of S6K1 at Thr389 in EGF- and insulin-stimulated HeLa cells, showing that mTORC1 activity is impaired[2].

化学信息

分子量	401.27
分子式	C₁₈H₁₀Cl₂N₄OS
CAS No.	1025821-33-3
Smiles	Clc1cccc(Cl)c1NC1=NC(=O)\C(S1)=C\c1ccc2nccnc2c1
密度	1.55 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 49 mg/mL (122.11 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.46 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4921 mL	12.4604 mL	24.9209 mL	124.6044 mL
5 mM	0.4984 mL	2.4921 mL	4.9842 mL	24.9209 mL
10 mM	0.2492 mL	1.2460 mL	2.4921 mL	12.4604 mL
20 mM	0.1246 mL	0.6230 mL	1.2460 mL	6.2302 mL
50 mM	0.0498 mL	0.2492 mL	0.4984 mL	2.4921 mL
100 mM	0.0249 mL	0.1246 mL	0.2492 mL	1.2460 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

GSK-626616

GSK-626616

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

GSK-626616

GSK-626616

GSK-626616 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词