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Phthalylsulfathiazole

Name: Phthalylsulfathiazole
Brand: TargetMol
SKU: T0512
Price: 113 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.16%

货号 T0512Cas号 85-73-4

别名 酞磺胺噻唑, Sulfathalidine, N4-Phthalylsulfathiazole

Phthalylsulfathiazole (N4-Phthalylsulfathiazole) 是磺胺类抗菌药。

Phthalylsulfathiazole

一键复制产品信息

很棒

纯度: 97.16%

货号 T0512 别名 酞磺胺噻唑, Sulfathalidine, N4-PhthalylsulfathiazoleCas号 85-73-4

Phthalylsulfathiazole (N4-Phthalylsulfathiazole) 是磺胺类抗菌药。

规格	价格	库存
200 mg	¥ 113	现货
500 mg	¥ 163	现货
1 g	¥ 226	现货
5 g	¥ 463	现货
10 g	¥ 637	待询
1 mL x 10 mM (in DMSO)	¥ 179	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 97.16%

颜色: 白色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Phthalylsulfathiazole AI Summary

Phthalylsulfathiazole exhibits a diverse range of bioactivities, including both activation and inhibition of Cytochrome P450 3A4 with a potent value of 1.3 nM. It also inhibits BAZ2B and 15-hLO-2 with potencies of 50118.7 nM and 15848.9 nM, respectively. In antiviral assays, it inhibits Ebola virus entry with AC50 values between 0.631 µM and 39810.7 nM and has shown potency in Foot and Mouth Disease Virus antiviral screenings with 316.2 nM. Additionally, the compound demonstrates inhibitory activity against OATP1B1 and OATP1B3 transporters at an equimolar concentration of 10 µM, with inhibition percentages of 115.53% and 107.02%. Regarding its pharmacokinetics, Phthalylsulfathiazole has a human intestinal absorption rate with a logarithmic value of log10(%HIA +10) = 1.176. Despite its diverse activities, it exhibits moderate liver toxicity, showing acute liver toxicity with a value of 1.0 and hepatotoxic effects but not severe chronic liver conditions. Concerning antiviral activity against SARS-CoV-2, Phthalylsulfathiazole has shown low inhibition in various assays, including inhibition of SARS-CoV-2 3CL-Pro protease and inhibition of cytotoxicity in VERO-6 cells, with some assays indicating values that reflect moderate to weak potency. Specific inhibition percentages include 12.83% and 39.87% in SARS-CoV-2 3CL-Pro protease assays and IC50 values above 20,000 nM. The compound also displays a variable inhibition rate in the enzymatic assay of human HDAC6, with -63.83% in one assay and 2.87% in another using different substrates. Although it binds to several human receptors and enzymes, most of its bioactivity results show low potency with AC50 values exceeding 30,000.0 nM. Overall, Phthalylsulfathiazole demonstrates significant but selective bioactivities across various biological assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Phthalylsulfathiazole (N4-Phthalylsulfathiazole) is a broad spectrum antimicrobial agent, used in the treatment of dysentery, colitis, and gastroenteritis.
别名	酞磺胺噻唑, Sulfathalidine, N4-Phthalylsulfathiazole

化学信息

分子量	403.43
分子式	C₁₇H₁₃N₃O₅S₂
CAS No.	85-73-4
Smiles	OC(=O)C1=CC=CC=C1C(=O)NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CS1
密度	1.4235 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (136.33 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4787 mL	12.3937 mL	24.7874 mL	123.9372 mL
5 mM	0.4957 mL	2.4787 mL	4.9575 mL	24.7874 mL
10 mM	0.2479 mL	1.2394 mL	2.4787 mL	12.3937 mL
20 mM	0.1239 mL	0.6197 mL	1.2394 mL	6.1969 mL
50 mM	0.0496 mL	0.2479 mL	0.4957 mL	2.4787 mL
100 mM	0.0248 mL	0.1239 mL	0.2479 mL	1.2394 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Phthalylsulfathiazole Inhibitor inhibit Bacterial Antibiotic

Phthalylsulfathiazole

Phthalylsulfathiazole