规格

价格

库存

数量

25 mg

¥ 10,600

6-8周

50 mg

¥ 13,800

6-8周

100 mg

¥ 17,500

6-8周

生物活性

产品描述	DC-5163 is a potent inhibitor of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with IC50 of 176.3 nM and Kd of 3.192 μM. DC-5163 selectively inhibits cancer cell proliferation and induces apoptosis, and partially inhibits the glycolysis pathway.
靶点活性	GAPDH:176.3 nM , GAPDH:(kd)3.192 μM
体外活性	DC-5163 (100 μM; 48 hours; MDA-MB-231 cells) treatment can obviously induce apoptosis of MDA-MB-231 cells. DC-5163 inhibited the proliferation of MDA-MB-231 cells with an IC50 of 49.22 μM at 48 hours and 52.09 μM at 72 hours. Compared with the experimental control, DC-5163 also significantly reduced glucose uptake, lactic acid production and 18F-FDG uptake rate. After treatment with 25μM DC-5163 for 48 hours, it can inhibit the GAPDH activity of BT-549 cells, MCF7 cells, HCT116 cells, MDA-MB-231 cells and A549 cells.

化学信息

分子量	361.89
分子式	C₁₈H₂₀ClN₃OS
CAS No.	897771-47-0
Smiles	C(N1CN(C(NC2=CC(Cl)=C(OC)C=C2)=S)CC1)C3=CC=CC=C3
密度	1.332 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 300 mg/mL (828.98 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 5 mg/mL (13.82 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO