Lomefloxacin hydrochloride

Name: Lomefloxacin hydrochloride
Brand: TargetMol
SKU: T1625
Price: 247 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.75%

货号 T1625Cas号 98079-52-8

别名 盐酸洛美沙星, Okacyn, Maxaquin, Lomefloxacin HCl

Lomefloxacin hydrochloride (Okacyn) 是一种广谱喹诺酮类抗生素，具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。

Lomefloxacin hydrochloride

一键复制产品信息

很棒

纯度: 99.75%

货号 T1625 别名 盐酸洛美沙星, Okacyn, Maxaquin, Lomefloxacin HClCas号 98079-52-8

Lomefloxacin hydrochloride (Okacyn) 是一种广谱喹诺酮类抗生素，具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。

规格	价格	库存
100 mg	¥ 247	现货
500 mg	¥ 372	现货
1 g	¥ 446	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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纯度: 99.75%

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COA HNMR LCMS 产品操作手册

产品介绍

Lomefloxacin hydrochloride AI Summary

Lomefloxacin hydrochloride shows high stability in human plasma and urine, with recovery rates ranging from 97.84% to 98.92% assessed through spectrofluorimetry, indicating good stability in these environments. It demonstrates antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 6309.57 nM to 10000.0 nM. The compound exhibits a diverse range of bioactivities, including inhibition of multiple targets such as HSD17B4, JMJD2E, ALDH1A1, PMP22, HPGD, TrxR1, and human TDP1, along with inhibiting entry of Marburg and Ebola viruses. Additionally, Lomefloxacin hydrochloride shows significant inhibition (101.03% and 75.12%) of sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells at 10 µM. It has an inhibition index of 0.3996 for cell viability in Vero E6 cells infected with SARS-CoV-2, and displays 0.88% inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours. Moreover, it inhibits SARS-CoV-2 3CL-Pro protease activity by 15.22% at a concentration of 20 µM and shows minimal inhibition (-0.11%) of SARS-CoV-2-induced cytotoxicity in Vero-6 cells at 10 µM after 48 hours. Furthermore, Lomefloxacin hydrochloride shows antibacterial activity against Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa PAO397 with MIC values from 312.5 nM to 625.0 nM and has an MIC of 10000.0 nM against Staphylococcus aureus MRSA. It lacks significant antifungal activity against Candida albicans and Cryptococcus neoformans (MIC > 20000.0 nM) and exhibits minimal haemolytic activity (HC10 > 20.0 uM) and low cytotoxicity against HEK293 cells (CC50 > 20000.0 nM)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

Lomefloxacin hydrochloride (Okacyn) inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis. Lomefloxacin Hydrochloride is the hydrochloride salt form of lomefloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity.

别名

盐酸洛美沙星, Okacyn, Maxaquin, Lomefloxacin HCl

化学信息

分子量	387.81
分子式	C₁₇H₂₀ClF₂N₃O₃
CAS No.	98079-52-8
Smiles	C1(NCCN(C1)c1c(cc2c(c1F)n(cc(c2=O)C(=O)O)CC)F)C.Cl
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 10 mg/mL (25.79 mM), Sonication is recommended.

DMSO: Insoluble

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.5786 mL	12.8929 mL	25.7858 mL	128.9291 mL
5 mM	0.5157 mL	2.5786 mL	5.1572 mL	25.7858 mL
10 mM	0.2579 mL	1.2893 mL	2.5786 mL	12.8929 mL
20 mM	0.1289 mL	0.6446 mL	1.2893 mL	6.4465 mL