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MG 149

Name: MG 149
Brand: TargetMol
SKU: T6584
Price: 397 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.86%

货号 T6584Cas号 1243583-85-8

别名 Tip60 HAT inhibitor, MG149

MG 149 (Tip60 HAT inhibitor) 是一种Tip60抑制剂，IC50为 74 μM。它对 MOF 的抑制性较相似，IC50为 47 μM。

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MG 149

一键复制产品信息

很棒

纯度: 99.86%

货号 T6584 别名 Tip60 HAT inhibitor, MG149Cas号 1243583-85-8

MG 149 (Tip60 HAT inhibitor) 是一种Tip60抑制剂，IC50为 74 μM。它对 MOF 的抑制性较相似，IC50为 47 μM。

规格	价格	库存
1 mg	¥ 397	现货
5 mg	¥ 975	现货
10 mg	¥ 1,490	现货
25 mg	¥ 2,670	现货
50 mg	¥ 4,120	现货
100 mg	¥ 5,880	现货
500 mg	¥ 11,900	现货
1 mL x 10 mM (in DMSO)	¥ 1,130	现货

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产品介绍

MG 149 AI Summary

MG 149 exhibits a broad range of bioactivities, prominently related to the inhibition of various histone acetyltransferases (HATs) including Tip60, PCAF, and p300 HAT domains. It competitively inhibits Tip60 with a Kis value of 54.0 µM and uncompetitively with a Kii value of 78.0 µM, effectively inhibiting Tip60-mediated histone acetylation in HeLa nuclear extracts, particularly impacting histone H3 and H4 acetylation with inhibition percentages exceeding 50.0%. Additionally, it inhibits the human His-tagged MOF enzyme with 100% inhibition at concentrations of 50 µM and 100 µM and shows IC50 values of 15000.0 nM and 27000.0 nM in respective radioactive acetylation and alphascreen assays. Beyond its activity in epigenetic regulation, MG 149 demonstrates potent bioactivity in various cell proliferation assays, cell lines including Plasmodium falciparum and ATL, as well as antagonism of the NFkB signaling pathway and cytotoxicity counterscreen, with potency in the nanomolar range. It also exhibits the ability to activate potato 5-lipoxygenase, evidenced by a fold change (FC) value of 3.0 at a 50 µM concentration. Moreover, it inhibits human COX2 with less than 50% inhibition using arachidonic acid as a substrate. Overall, MG 149 targets multiple biological pathways, suggesting potential as a versatile modulator of both epigenetic and cellular processes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
靶点活性	Tip60:74 μM, MOF:47 μM
别名	Tip60 HAT inhibitor, MG149

化学信息

分子量	340.46
分子式	C₂₂H₂₈O₃
CAS No.	1243583-85-8
Smiles	CCCCCCCc1ccc(CCc2cccc(O)c2C(O)=O)cc1
密度	1.100 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 63 mg/mL (185.04 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 255 mg/mL (748.99 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.87 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9372 mL	14.6860 mL	29.3720 mL	146.8601 mL
5 mM	0.5874 mL	2.9372 mL	5.8744 mL	29.3720 mL
10 mM	0.2937 mL	1.4686 mL	2.9372 mL	14.6860 mL
20 mM	0.1469 mL	0.7343 mL	1.4686 mL	7.3430 mL
50 mM	0.0587 mL	0.2937 mL	0.5874 mL	2.9372 mL
100 mM	0.0294 mL	0.1469 mL	0.2937 mL	1.4686 mL