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Tizoxanide

Name: Tizoxanide
Brand: TargetMol
SKU: T2279
Price: 163 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.28%

货号 T2279Cas号 173903-47-4

别名 替唑尼特, TIZ, Desacetyl-nitazoxanide

Tizoxanide (Desacetyl-nitazoxanide) 是 Nitazoxanide 活性代谢物，有抗HIV-1的活性。Nitazoxanide 可抗细菌和多种病毒复制。

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Tizoxanide

一键复制产品信息

很棒

纯度: 99.28%

货号 T2279 别名 替唑尼特, TIZ, Desacetyl-nitazoxanideCas号 173903-47-4

Tizoxanide (Desacetyl-nitazoxanide) 是 Nitazoxanide 活性代谢物，有抗HIV-1的活性。Nitazoxanide 可抗细菌和多种病毒复制。

规格	价格	库存
1 mg	¥ 163	现货
2 mg	¥ 223	现货
5 mg	¥ 359	现货
10 mg	¥ 578	现货
25 mg	¥ 1,050	现货
50 mg	¥ 1,620	现货
100 mg	¥ 2,420	现货
1 mL x 10 mM (in DMSO)	¥ 443	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 98.89%

颜色: 白色

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COA LCMS HNMR HPLC 产品操作手册

产品介绍

Tizoxanide AI Summary

Tizoxanide exhibits a broad spectrum of bioactivities, including antimicrobial, antiviral, antiprotozoan, and antitumor properties. It inhibits Giardia lamblia recombinant nitroreductase 1 in Escherichia coli with more than 75% inhibition at 5 μM, and shows activity against Clostridium difficile with MIC50 of 0.06 μg/mL and MIC90 of 0.125 μg/mL. Against Mycobacterium tuberculosis H37Rv, it has a Minimum Inhibitory Concentration (MIC) of 16.0 μg/mL in liquid medium after 7 days. It demonstrates antiviral efficacy against HCV genotypes 1a and 1b with EC50 values ranging from 150.0 nM to 2.0 μM and cytotoxicity in human cells with CC50 values of 14,000.0 nM to 92,000.0 nM, along with high selectivity indices. It also exhibits potent antiviral activity against HBV with EC50 values of 150.0 nM and 460.0 nM and low toxicity (CC50 > 100,000.0 nM). For HBV-infected HepG2(2.2.15) cells, it inhibits extracellular and intracellular viral DNA with EC90 values of 0.58 μM and 1.2 μM respectively. Against Trichomonas vaginalis, it has an IC50 of 211.0 nM and displays antiprotozoan activity against various pathogens, including Giardia intestinalis and Leishmania mexicana. The compound shows antimicrobial activity against Mycobacterium tuberculosis in both replicating and non-replicating states with a MIC of 60,380.0 nM, and against Staphylococcus epidermidis with a MIC of 8.0 μg/mL. It has been reported to exert antitumor growth inhibition across multiple human cancer cell lines with GI50 values ranging from 3,000 nM to 40,000 nM. Additionally, Tizoxanide inhibits IL-6 induced STAT3 transcriptional activity in HEK-Blue IL-6 cells, showing 60% inhibition at 10 μM and an IC50 of 8,900.0 nM, while exhibiting 12.7% cytotoxicity in HeLa cells. In animal models, it has a rapid elimination half-life of 0.7 hours in Sprague-Dawley rats when administered via oral gavage. Furthermore, it demonstrates binding affinity with human plasma proteins at 97.5% and a favorable selectivity index, indicating potential therapeutic applications across various medical conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine. Lamivudine (2', 3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).
别名	替唑尼特, TIZ, Desacetyl-nitazoxanide

化学信息

分子量	265.25
分子式	C₁₀H₇N₃O₄S
CAS No.	173903-47-4
Smiles	Oc1ccccc1C(=O)Nc1ncc(s1)[N+]([O-])=O
密度	1.644 g/cm3 (Predicted)

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 20 mg/mL (75.4 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7700 mL	18.8501 mL	37.7003 mL	188.5014 mL
5 mM	0.7540 mL	3.7700 mL	7.5401 mL	37.7003 mL
10 mM	0.3770 mL	1.8850 mL	3.7700 mL	18.8501 mL
20 mM	0.1885 mL	0.9425 mL	1.8850 mL	9.4251 mL
50 mM	0.0754 mL	0.3770 mL	0.7540 mL	3.7700 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。