SB-200646

Name: SB-200646
Brand: TargetMol
SKU: T8357
Price: 452 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T8357Cas号 143797-63-1 一键复制产品信息纯度: 99.61%

很棒

SB-200646 是 5-HT2B/5-HT2C 受体的选择性强效拮抗剂，对5-HT2B、5-HT2C 和 5-HT2A 的pKi 值分别为 7.5、6.9 和 5.2。它有口服活性，在体内具有电生理和抗焦虑特性。

SB-200646

一键复制产品信息

很棒

纯度: 99.61%

货号 T8357Cas号 143797-63-1

SB-200646 是 5-HT2B/5-HT2C 受体的选择性强效拮抗剂，对5-HT2B、5-HT2C 和 5-HT2A 的pKi 值分别为 7.5、6.9 和 5.2。它有口服活性，在体内具有电生理和抗焦虑特性。

规格	价格	库存
1 mg	¥ 452	现货
5 mg	¥ 1,110	现货
10 mg	¥ 1,780	现货
25 mg	¥ 3,110	现货
50 mg	¥ 4,420	现货
100 mg	¥ 5,950	现货
1 mL x 10 mM (in DMSO)	¥ 1,000	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.61%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

SB-200646 AI Summary

SB-200646 shows high binding affinity for the 5-HT2B receptor (Ki value of 21.0 nM) in rat stomach fundus, and moderate affinity for the 5-HT2C receptor, with very low affinity for the 5-HT2A receptor, suggesting a selectivity toward the 5-HT2B receptor. It exhibits multiple bioactivities, including inhibitory effects on various targets such as menin-MLL interactions in MLL-related leukemias, RECQ1 DNA helicase, human JMJD2E, tyrosyl-DNA phosphodiesterase, Tau fibril formation, Cruzain, Cytochrome P450 enzymes, and ROR gamma transcriptional activity. It also modulates lipid storage, blocks interactions between CBF-beta and RUNX1 in acute myeloid leukemia, and prevents cellular entry by Lassa and Marburg viruses. Additionally, SB-200646 shows antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, with inhibition rates of -4.21% and 0.09% at 10 μM concentration after 48 hours respectively, and by inhibiting SARS-CoV-2 3CL-Pro protease activity by 18.71% at 20 μM. It also exhibits significant enzymatic inhibitory activity against human HDAC6, with inhibition percentages ranging from 39.59% to 88.14%, indicating its potential as an HDAC6 inhibitor. These bioactivities suggest that SB-200646 has diverse pharmacological effects related to serotonin receptor modulation, antiviral activity, and inhibition of key enzymatic pathways, offering potential therapeutic applications in various diseases and conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor
靶点活性	5-HT2A receptor:5.2 (pKi), 5-HT2B receptor:7.5 (pKi) , 5-HT2C receptor:6.9 (pKi)

化学信息

分子量	266.3
分子式	C₁₅H₁₄N₄O
CAS No.	143797-63-1
Smiles	CN1C=2C(=CC(NC(NC=3C=CC=NC3)=O)=CC2)C=C1
密度	1.26g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 53 mg/mL (199.02 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7552 mL	18.7758 mL	37.5516 mL	187.7582 mL
5 mM	0.7510 mL	3.7552 mL	7.5103 mL	37.5516 mL
10 mM	0.3755 mL	1.8776 mL	3.7552 mL	18.7758 mL
20 mM	0.1878 mL	0.9388 mL	1.8776 mL	9.3879 mL
50 mM	0.0751 mL	0.3755 mL	0.7510 mL	3.7552 mL
100 mM	0.0376 mL	0.1878 mL	0.3755 mL	1.8776 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。