规格

价格

库存

数量

1 mg

¥ 117

现货

5 mg

¥ 263

现货

10 mg

¥ 440

现货

25 mg

¥ 953

现货

50 mg

¥ 1,530

现货

100 mg

¥ 2,470

现货

200 mg

¥ 3,470

现货

1 mL x 10 mM (in DMSO)

¥ 317

现货

生物活性

产品描述	KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA).
靶点活性	2-AG:2.5 nM, AEA:>50 μM, MAGL (mouse):15 nM, MAGL (human):5.9 nM, MAGL (rat):43 nM
体内活性	DprE1-IN-2 has efficacy in a rodent model of tuberculosis.

化学信息

分子量	549.42
分子式	C₂₄H₂₁F₆NO₇
CAS No.	1380424-42-9
Smiles	OC(C1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)(c1ccc2OCOc2c1)c1ccc2OCOc2c1
密度	1.511 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (91.01 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.64 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO