Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)

Lansoprazole对缺血-再灌注或吲哚美辛诱发的肠损伤有明显的抑制作用.外源施用Lansoprazol可以防止小肠中缺血-再灌注或吲哚美辛诱导的损伤.Lansoprazole抑制缺血-再灌注或吲哚美辛诱导的大鼠急性炎性反应以及肠粘膜损伤.

Lansoprazole是一种很强的抗分泌剂,通过抑制胃氢/钾的腺苷三磷酸酶抑制胃酸分泌（H +,K + - ATP酶）。Lansoprazole抑制血管粘附分子的表达增加,中性粒细胞的激活,以及从激活的内皮细胞产生促炎细胞因子。Lansoprazole在胃上皮细胞中诱导包括II期解毒酶（NADPH-泛醌氧化还原酶,谷胱甘肽S-转移酶）和抗氧化应激蛋白（HO-1,硫氧还蛋白还原酶和超氧化物歧化酶）在内的多种基因的表达。Lansoprazole在大鼠胃上皮细胞中,上调HO-1表达,并且有抗炎作用。