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SRI-29329

Name: SRI-29329
Brand: TargetMol
SKU: T8801
Price: 828 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.18%

货号 T8801Cas号 2086809-58-5

SRI-29329 是一种有效的、特异性的 CDC 样激酶抑制剂，对 CLK1、CLK2 和 CLK4 的 IC50 分别为 78 nM、16 nM 和 86 nM。

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SRI-29329

一键复制产品信息

很棒

纯度: 99.18%

货号 T8801Cas号 2086809-58-5

SRI-29329 是一种有效的、特异性的 CDC 样激酶抑制剂，对 CLK1、CLK2 和 CLK4 的 IC50 分别为 78 nM、16 nM 和 86 nM。

规格	价格	库存
1 mg	¥ 828	现货
5 mg	¥ 1,950	现货
10 mg	¥ 3,130	现货
25 mg	¥ 5,130	现货
50 mg	¥ 7,290	现货
100 mg	¥ 9,830	现货
1 mL x 10 mM (in DMSO)	¥ 2,220	现货

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COA LCMS HNMR 产品操作手册

产品介绍

SRI-29329 AI Summary

SRI-29329 exhibits bioactivity as a potent inhibitor of several kinases, particularly CLK2 with an IC50 of 16.0 nM, CLK1 with an IC50 of 78.0 nM, and human CLK4 with an IC50 of 86.0 nM. It demonstrates selectivity towards CLK1 over CLK2 with a selectivity ratio of 5.0. Additionally, the compound exhibits moderate inhibitory activity against MEKK2, Plk1, and Src kinases and inhibits CLK-mediated SF3B1 activation in human SK-MEL-2 cells with an EC50 of 11700.0 nM. SRI-29329 has varying effects on cell viability; in HEK293T cells, it shows a tendency to decrease cell growth rates, while in U2OS cells and human fibroblasts, the effects are mixed. Thermal Shift Assays reveal that SRI-29329 affects the melting temperature (TM) of different protein domains variably, either stabilizing or destabilizing them. This suggests that the compound interacts differently with various protein regions, potentially impacting their stability and function..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).
靶点活性	CLK2:16 nM , CLK1:78 nM , CLK4:86 nM

化学信息

分子量	399.92
分子式	C₂₀H₂₆ClN₇
CAS No.	2086809-58-5
Smiles	CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 32.5 mg/mL (81.27 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5005 mL	12.5025 mL	25.0050 mL	125.0250 mL
5 mM	0.5001 mL	2.5005 mL	5.0010 mL	25.0050 mL
10 mM	0.2501 mL	1.2503 mL	2.5005 mL	12.5025 mL
20 mM	0.1250 mL	0.6251 mL	1.2503 mL	6.2513 mL
50 mM	0.0500 mL	0.2501 mL	0.5001 mL	2.5005 mL