Antibacterial agent 27

Name: Antibacterial agent 27
Brand: TargetMol
SKU: T9612
Price: 358 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.91%

货号 T9612Cas号 65795-51-9

Antibacterial agent 27 是抗菌化合物，显示出有效的抗念珠菌活性。

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Antibacterial agent 27

一键复制产品信息

很棒

纯度: 98.91%

货号 T9612Cas号 65795-51-9

Antibacterial agent 27 是抗菌化合物，显示出有效的抗念珠菌活性。

规格	价格	库存
1 mg	¥ 358	现货
5 mg	¥ 893	现货
10 mg	¥ 1,420	现货
25 mg	¥ 2,680	现货
50 mg	¥ 3,760	现货
100 mg	¥ 5,070	现货
200 mg	¥ 6,830	现货
1 mL x 10 mM (in DMSO)	¥ 978	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 98.91%

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产品介绍

Antibacterial agent 27 AI Summary

Antibacterial agent 27 exhibits diverse and potent bioactivities, targeting a range of organisms and enzymes. It effectively inhibits Plasmodium falciparum, showing 92.0% inhibition of the 3D7 strain and 95.0% inhibition of the Dd2 strain in whole erythrocytes at 2 μM concentration. Additionally, it exhibits an XC50 value of 3.29 nM against the 3D7 strain. The compound has an Inhibition Frequency Index (IFI) of 5.0% in non-kinase HTS assays with >50% inhibition and demonstrates 64.0% inhibition of the human HepG2 cell line at a 10 μM concentration. Against Leishmania Mexicana, Antibacterial agent 27 shows significant cytotoxicity against glucose transport-deficient promastigotes and those complemented with various glucose transporters, with IC50 values ranging from 537.0 nM to 777.0 nM and inhibition percentages between 77.74% and 84.19% at 2 μM concentration. This suggests the compound may target glucose transport mechanisms in Leishmania parasites. Regarding mammalian cell lines, Antibacterial agent 27 is cytotoxic to mouse L1210 cells with an IC50 of 40.0 nM. It is also a potent inhibitor of dihydrofolate reductase (DHFR), with IC50 values of 6.4 nM in Lactobacillus casei, 0.7 nM in Crithidia oncopelti, 2.1 nM in rat liver DHFR, and 4.0 nM in mouse L1210 cells. Furthermore, it inhibits human DHFR and Mycobacterium tuberculosis DHFR with IC50 values of 6.8 nM and 10.1 nM, respectively. The compound also shows antimicrobial activity against Mycobacterium tuberculosis H37Rv in human THP1 cells, with a MIC90 value of 500.0 nM. These findings indicate that Antibacterial agent 27 has significant cytotoxic, antimalarial, anti-leishmanial, and antimicrobial properties, making it a promising candidate for further drug development..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Antibacterial agent 27 has potent anti-Candida activity.

化学信息

分子量	314.34
分子式	C₁₈H₁₄N₆
CAS No.	65795-51-9
Smiles	Nc1nc(N)c2c3ccn(Cc4ccc(cc4)C#N)c3ccc2n1
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (318.13 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.73 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1813 mL	15.9063 mL	31.8127 mL	159.0634 mL
5 mM	0.6363 mL	3.1813 mL	6.3625 mL	31.8127 mL
10 mM	0.3181 mL	1.5906 mL	3.1813 mL	15.9063 mL
20 mM	0.1591 mL	0.7953 mL	1.5906 mL	7.9532 mL
50 mM	0.0636 mL	0.3181 mL	0.6363 mL	3.1813 mL
100 mM	0.0318 mL	0.1591 mL	0.3181 mL	1.5906 mL