4-Nonylphenylboronic acid

Name: 4-Nonylphenylboronic acid
Brand: TargetMol
SKU: T7688
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.63%

货号 T7688Cas号 256383-45-6

别名 4-壬基苯硼酸

4-Nonylphenylboronic acid 是 FAAH 的抑制剂。

4-Nonylphenylboronic acid

一键复制产品信息

很棒

纯度: 97.63%

货号 T7688 别名 4-壬基苯硼酸Cas号 256383-45-6

4-Nonylphenylboronic acid 是 FAAH 的抑制剂。

规格	价格	库存	数量
50 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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产品介绍

4-Nonylphenylboronic acid AI Summary

4-Nonylphenylboronic acid is a multifunctional inhibitor with diverse biological activities. It notably inhibits the fatty acid amide hydrolase (FAAH) enzyme in Wistar rat brain with a potent IC50 of 9.1 nM and exerts inhibitory effects on the human recombinant monoacylglycerol lipase (MGL) enzyme with an IC50 of 7900.0 nM. It also targets lipid metabolism enzymes, exhibiting an IC50 of 1000.0 nM for human endothelial lipase and 42000.0 nM for human lipoprotein lipase in vesicle assays, with a selectivity ratio of 42.0. In micelle assays, it shows an IC50 of 100.0 nM for human endothelial lipase and 1400.0 nM for human lipoprotein lipase, with a selectivity ratio of 14.0. Additionally, it inhibits rat brain FAAH with an IC50 of 2920.0 nM and acts as an antagonist at recombinant human TRPV1 channels with an IC50 of 9100.0 nM, despite having less than 10.0% efficacy as an agonist at these channels. 4-Nonylphenylboronic acid has demonstrated antiviral bioactivity, showing a 24.57% inhibition of SARS-CoV-2 3CL-Pro protease and a modest inhibition rate of 1.29% against SARS-CoV-2 induced cytotoxicity in VERO-6 cells at a 10 µM concentration over 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	4-Nonylphenylboronic acid is a inhibitor of FAAH.
别名	4-壬基苯硼酸

化学信息

分子量	248.17
分子式	C₁₅H₂₅BO₂
CAS No.	256383-45-6
Smiles	CCCCCCCCCc1ccc(cc1)B(O)O
密度	0.97 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 9 mg/mL (36.27 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0295 mL	20.1475 mL	40.2950 mL	201.4748 mL
5 mM	0.8059 mL	4.0295 mL	8.0590 mL	40.2950 mL
10 mM	0.4029 mL	2.0147 mL	4.0295 mL	20.1475 mL
20 mM	0.2015 mL	1.0074 mL	2.0147 mL	10.0737 mL