Ceftazidime

Name: Ceftazidime
Brand: TargetMol
SKU: T1305
Price: 196 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.85%

货号 T1305Cas号 72558-82-8

别名 头孢他啶, GR20263

Ceftazidime (GR20263) 是可静脉内或肌肉给药的第头孢菌素。它对革兰氏阳性和革兰氏阴性需氧细菌有体外活性。它对肠杆菌科特别有效，对大多数 β-内酰胺酶具有抗水解作用。

Ceftazidime

一键复制产品信息

很棒

纯度: 99.85%

货号 T1305 别名 头孢他啶, GR20263Cas号 72558-82-8

规格	价格	库存
100 mg	¥ 196	现货
500 mg	¥ 418	现货
1 g	¥ 544	现货
5 g	¥ 980	现货
1 mL x 10 mM (in DMSO)	¥ 460	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

Ceftazidime AI Summary

Ceftazidime demonstrates broad-spectrum antimicrobial activity against a variety of bacterial strains, including Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus, and several others. The compound shows varying levels of minimum inhibitory concentration (MIC) values, ranging from as low as 0.03 ug/mL to over 256.0 ug/mL, depending on the specific bacterial strain and their resistance mechanisms. It is particularly potent against certain beta-lactamase producing strains, such as those with CTX-M, TEM, and SHV enzymes, and has shown inhibition of bacterial growth even in the presence of resistance genes like OXA, VIM, and KPC. The compound exhibits effectiveness in both in vitro and in vivo models, with additional pharmacokinetic data indicating a short plasma half-life and significant urinary recovery, especially in rats and marmosets. Moreover, Ceftazidime demonstrates synergy with beta-lactamase inhibitors like clavulanic acid, enhancing its antibacterial effects. Despite its promising antimicrobial properties, the compound shows reduced efficacy against specific resistant strains such as imipenem-resistant Acinetobacter baumannii and certain multidrug-resistant Pseudomonas aeruginosa isolates. Overall, Ceftazidime holds potential as a valuable antimicrobial agent capable of combating a wide range of bacterial infections, particularly those involving beta-lactamase producing and multidrug-resistant pathogens. Further studies into its mechanism of action, optimal dosing strategies, and combination therapies could expand its clinical utility..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ceftazidime (GR20263) is a beta-lactam, cephalosporin antibiotic with bactericidal activity.
别名	头孢他啶, GR20263

化学信息

分子量	546.58
分子式	C₂₂H₂₂N₆O₇S₂
CAS No.	72558-82-8
Smiles	CC(C)(O\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[n+]3ccccc3)=C(N2C1=O)C(O)=O)c1csc(=N)[nH]1)C([O-])=O
密度	no data available

储存&溶解度

存储

store under nitrogen,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 20.1 mg/mL (36.77 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.66 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8296 mL	9.1478 mL	18.2956 mL	91.4779 mL
5 mM	0.3659 mL	1.8296 mL	3.6591 mL	18.2956 mL
10 mM	0.1830 mL	0.9148 mL	1.8296 mL	9.1478 mL
20 mM	0.0915 mL	0.4574 mL	0.9148 mL	4.5739 mL