购物车
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部相关产品产品介绍化学信息储存和溶解信息计算器

Protein kinase inhibitor H-7 dihydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 99.81%

货号 T22831Cas号 108930-17-2

别名 H-7 dihydrochloride

Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride0) 是一种有效的蛋白激酶 C（PKC）抑制剂。Protein kinase inhibitor H-7 dihydrochloride（100 μM）显著抑制 TPA (皮肤肿瘤启动子，12-O-tetradecanoylphorbol-13-acetate) 和磷脂酶 C 促使的 ODC (鸟氨酸脱羧酶)，抑制 PMA 诱导的混杂细胞溶解活性。

Protein kinase inhibitor H-7 dihydrochloride
其他形式的 “Protein kinase inhibitor H-7 dihydrochloride”:
H7
Protein kinase inhibitor H-7

Protein kinase inhibitor H-7 dihydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 99.81%

货号 T22831 别名 H-7 dihydrochlorideCas号 108930-17-2

Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride0) 是一种有效的蛋白激酶 C（PKC）抑制剂。Protein kinase inhibitor H-7 dihydrochloride（100 μM）显著抑制 TPA (皮肤肿瘤启动子，12-O-tetradecanoylphorbol-13-acetate) 和磷脂酶 C 促使的 ODC (鸟氨酸脱羧酶)，抑制 PMA 诱导的混杂细胞溶解活性。

规格价格库存数量
2 mg
¥ 113
现货
5 mg
¥ 191
现货
10 mg
¥ 331
现货
25 mg
¥ 697
现货
50 mg
¥ 1,110
现货
100 mg
¥ 1,770
现货
200 mg
¥ 2,490
现货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
选择批次:
纯度: 99.81%
联系我们 获取更多批次信息
资源下载:
COA LCMS HNMR产品操作手册

产品介绍

生物活性
产品描述
Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor. Protein kinase inhibitor H-7 dihydrochloride (100 μM) significantly inhibits TPA (skin tumor promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) inhibited PMA-induced promiscuity cell lysis activity.
别名H-7 dihydrochloride
化学信息
分子量364.29
分子式C14H19Cl2N3O2S
CAS No.108930-17-2
SmilesCl.Cl.CC1CNCCN1S(=O)(=O)c1cccc2cnccc12
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 55 mg/mL (150.98 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.7451 mL13.7253 mL27.4507 mL137.2533 mL
5 mM0.5490 mL2.7451 mL5.4901 mL27.4507 mL
10 mM0.2745 mL1.3725 mL2.7451 mL13.7253 mL
20 mM0.1373 mL0.6863 mL1.3725 mL6.8627 mL
50 mM0.0549 mL0.2745 mL0.5490 mL2.7451 mL
100 mM0.0275 mL0.1373 mL0.2745 mL1.3725 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

TargetMol AI Summary
Protein kinase inhibitor H-7 dihydrochloride exhibits a range of bioactivities, including the inhibition of protein kinase C (PKC) with an IC50 of 6000.0 nM and cAMP-dependent protein kinase (PKA) with an IC50 of 3500.0 nM. It displaces ATP from PKC with a Ki of 6000.0 nM and from PKA with a Ki of 3000.0 nM. Additionally, it demonstrates antiplasmodial activity against Plasmodium falciparum strains 7G8, GB4, and W2 with IC50 values between 6309.57 nM and 12589.25 nM. Further functionalities include modulating Lamin A splicing, inducing the erasure of genomic imprints, enhancing SMN2 splice variant expression, and inhibiting Aldehyde Dehydrogenase 1 (ALDH1A1). Protein kinase inhibitor H-7 dihydrochloride also modulates Human Peripheral Myelin Protein 22 (PMP22) expression, induces DNA re-replication in MCF 10A cells, inhibits MPP8 chromodomain interactions with methylated histone tails, acts as an hERG channel inhibitor, and inhibits the binding or entry of Marburg Virus into cells..
Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

PKCH7 DihydrochlorideH-7H7H 7 DihydrochlorideH 7
Related Tags: buy Protein kinase inhibitor H-7 dihydrochloride | purchase Protein kinase inhibitor H-7 dihydrochloride | Protein kinase inhibitor H-7 dihydrochloride cost | order Protein kinase inhibitor H-7 dihydrochloride | Protein kinase inhibitor H-7 dihydrochloride chemical structure | Protein kinase inhibitor H-7 dihydrochloride formula | Protein kinase inhibitor H-7 dihydrochloride molecular weight