Name: CPI203
Brand: TargetMol
SKU: T2442
Price: 116 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 116

现货

5 mg

¥ 250

现货

10 mg

¥ 442

现货

25 mg

¥ 696

现货

50 mg

¥ 1,270

现货

100 mg

¥ 2,310

现货

1 mL x 10 mM (in DMSO)

¥ 250

现货

产品介绍

生物活性

产品描述	CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
靶点活性	BET BD:37 nM
体外活性	CPI203 在体外及细胞内抑制BRD4，而不影响其体外的激酶活性。[1] CPI203 在分析的所有9个MCL细胞系中显示出细胞静止效果，GI50范围从0.06到0.71 μM，对健康捐献者的正常PBMCs具有低细胞性毒性。此外，lenalidomide和CPI203通过靶向IRF4和MYC，有效激活对bortezomib有抵抗性的MCL细胞中的细胞死亡程序。[2]
激酶实验	BRD4 α-screen assay: The BRD4 α-screen assay is a proximity-based assay using a tetraacteylated H4 peptide and the isolated bromodomain 1 of human BRD4. IC50 values are calculated using a 10-point serial dilution of BET inhibitor.
细胞实验	MCL primary cells and cell lines are incubated as indicated with lenalidomide and/or CPI203. MTT is added for 2-6 additional hours before spectrophotometric measurement. Each measurement is made in triplicate. Values are represented using untreated control cells. The GI50 is calculated as the concentration that produced 50 % growth inhibition. Combination indexes (CIs) are calculated by using the Calcusyn software version 2.0. The interaction between two drugs is considered synergistic when CI <1. (Only for Reference)
别名	CPI-203, CPI 203

化学信息

分子量	399.9
分子式	C₁₉H₁₈ClN₅OS
CAS No.	202591-23-9
Smiles	CC=1C2=C(N3C(C(CC(N)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C
密度	1.51 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 200 mM, Sonication is recommended.

溶液配制表

DMSO

体内实验配液计算器