Name: D-F07
Brand: TargetMol
SKU: T84311
Price: 780 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 780

现货

5 mg

¥ 1,950

现货

10 mg

¥ 2,850

现货

25 mg

¥ 4,480

现货

50 mg

¥ 5,920

现货

100 mg

¥ 8,160

现货

生物活性

产品描述	D-F07 belongs to fluorescent dye-class tricyclic chromone compounds and is an IRE1 inhibitor (prodrug form containing an aldehyde-masked group) with cell permeability. This compound induces tumor cell apoptosis through inhibition of the IRE1/XBP1 pathway, exhibiting significant antitumor activity, and is suitable for related mechanism research and antitumor drug development.
体外活性	方法：采用琼脂孔扩散法,在接种金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌和肺炎克雷伯菌的平板上，加入50 μl或100 μl该菌株D-F07培养上清液，孵育2天后测量抑菌圈直径。结果： 100 μlD-F07培养上清液对四种病原菌均产生明显抑菌圈。[1] 方法：在5TGM1小鼠骨髓瘤细胞中，D-F07以10 μM处理3天。结果：免疫印迹显示其持续抑制XBP-1s表达。XTT法检测表明，20 μM D-F07处理3天显著抑制细胞增殖，且效果强于非甲氧基取代的类似物。[2]
别名	DF07, D F07

化学信息

分子量	347.36
分子式	C₁₈H₂₁NO₆
CAS No.	2361297-58-5
Smiles	O=C1OC2=C(C=C(OC)C(O)=C2C3OCCCO3)C4=C1CN(C)CC4
密度	no data available

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

D-F07