BCL6-IN-3

Name: BCL6-IN-3
Brand: TargetMol
SKU: T10487
Price: 7680 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.17%

货号 T10487Cas号 2253878-44-1

BCL6-IN-3是一种有效的BCL6抑制剂，对SU-DHL4细胞中的GI50为70 nM。BCL6- in -3调控细胞活化、分化、DNA 损伤和凋亡过程，具有抗肿瘤活性。

为众多的药物研发团队赋能，

让新药发现更简单！

BCL6-IN-3

一键复制产品信息

很棒

纯度: 98.17%

货号 T10487Cas号 2253878-44-1

BCL6-IN-3是一种有效的BCL6抑制剂，对SU-DHL4细胞中的GI50为70 nM。BCL6- in -3调控细胞活化、分化、DNA 损伤和凋亡过程，具有抗肿瘤活性。

规格	价格	库存
1 mg	¥ 774	现货
5 mg	¥ 1,790	现货
10 mg	¥ 2,630	现货
25 mg	¥ 4,140	现货
50 mg	¥ 5,680	现货
100 mg	¥ 7,680	现货
500 mg	待询	现货
1 mL x 10 mM (in DMSO)	¥ 2,750	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.17%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

BCL6-IN-3 AI Summary

BCL6-IN-3 demonstrates significant potential as a BCL6 inhibitor, exhibiting an IC50 of 520.0 nM for human BCL6 inhibition. It effectively induces degradation of BCL6 in various human cell lines, with DC50 values ranging between 0.049 µM and 0.09 µM. The compound shows antiproliferative activity against multiple human cell lines, with GI50 values from 35.0 nM to 1600.0 nM. It also displays good kinetic solubility in HEPES and PBS buffers and possesses a metabolic stability with a clearance rate of 78.0 mL·min⁻¹·g⁻¹ in CD-1 mouse liver microsomes. BCL6-IN-3 has a log D value of 4.3, indicating its lipophilicity, and shows good oral bioavailability at 54.0% in BALB/c mice. Additional pharmacokinetic parameters include a short half-life of 1.4 hours and a moderate volume of distribution at steady state of 2.1 L·kg⁻¹. Furthermore, the compound has high protein binding with 99.96% bound to plasma proteins in BALB/c mice. These attributes highlight BCL6-IN-3's potential in therapeutic applications targeting BCL6 with promising bioavailability and solubility profiles..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.
靶点活性	Proliferation (SU-DHL4 cells):70 nM (GI50)

化学信息

分子量	508.99
分子式	C₂₄H₃₁ClF₂N₆O₂
CAS No.	2253878-44-1
Smiles	C(CC(C)(C)O)N1C=2C(N(C)C1=O)=CC=C(NC3=NC(=NC=C3Cl)N4C[C@H](C)C(F)(F)[C@H](C)C4)C2
密度	1.38 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 180 mg/mL (353.64 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9647 mL	9.8234 mL	19.6468 mL	98.2338 mL
5 mM	0.3929 mL	1.9647 mL	3.9294 mL	19.6468 mL
10 mM	0.1965 mL	0.9823 mL	1.9647 mL	9.8234 mL
20 mM	0.0982 mL	0.4912 mL	0.9823 mL	4.9117 mL
50 mM	0.0393 mL	0.1965 mL	0.3929 mL	1.9647 mL
100 mM	0.0196 mL	0.0982 mL	0.1965 mL	0.9823 mL