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OPG Protein, Mouse, Recombinant (His)

OPG Protein, Mouse, Recombinant (His)

产品编号 TMPJ-00253
别名: Opg, Ocif, Tnfrsf11b, Osteoclastogenesis inhibitory factor, Osteoprotegerin, Tumor necrosis factor receptor superfamily member 11B

Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG inhibits TRAIL-induced apoptosis. Expression of RANK L on the cell surface, and thus its ability to stimulate osteoclastogenesis, is regulated by OPG by intracellular and extracellular mechanisms. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. It may also play a role in preventing arterial calcification.

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OPG Protein, Mouse, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 700 5日内发货
50 μg ¥ 1,970 5日内发货
500 μg ¥ 8,860 5日内发货
1 mg ¥ 12,600 5日内发货
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产品目录号及名称: OPG Protein, Mouse, Recombinant (His) (TMPJ-00253)
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产品描述 Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG inhibits TRAIL-induced apoptosis. Expression of RANK L on the cell surface, and thus its ability to stimulate osteoclastogenesis, is regulated by OPG by intracellular and extracellular mechanisms. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. It may also play a role in preventing arterial calcification.
种属 Mouse
表达系统 HEK293 Cells
标签 C-10xHis
蛋白编号 O08712
别名 Opg, Ocif, Tnfrsf11b, Osteoclastogenesis inhibitory factor, Osteoprotegerin, Tumor necrosis factor receptor superfamily member 11B
氨基酸序列 Glu22-Leu401
蛋白构建 Glu22-Leu401
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 50-65 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG inhibits TRAIL-induced apoptosis. Expression of RANK L on the cell surface, and thus its ability to stimulate osteoclastogenesis, is regulated by OPG by intracellular and extracellular mechanisms. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. It may also play a role in preventing arterial calcification.

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Keywords

OPG Protein, Mouse, Recombinant (His) Opg Ocif Tnfrsf11b Osteoclastogenesis inhibitory factor Osteoprotegerin Tumor necrosis factor receptor superfamily member 11B recombinant recombinant-proteins proteins protein

 

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